急性缺血性脑卒中患者血清Apelin-13水平变化及其临床意义

发布时间：2018-04-11 10:36

本文选题：急性缺血性脑卒中 + Apelin-　；参考：《山东医药》2017年27期

【摘要】：目的观察急性缺血性脑卒中血清Apelin-13水平变化,并探讨其临床意义。方法选择急性缺血性卒中患者150例为病例组,选择来院体检的志愿者80例为对照组。病例组于入院第1、7、14天,对照组于体检当日,采用ELISA法检测血清Apelin-13。分别于入院第1、7、14天对病例组患者进行美国国立卫生研究院卒中量表(NIHSS)评分,分析血清Apelin-13水平与NIHSS评分的相关性。对病例组随访3个月,根据改良Rankin量表(mRS)评分评价近期预后,比较不同预后(残疾与非残疾)患者血清Apelin-13水平。结果病例组入院第1、7、14天血清Apelin-13水平分别为(0.34±0.05)、(0.57±0.03)、(0.76±0.04)ng/m L,对照组为(1.43±0.07)ng/m L。病例组入院第1、7、14天时血清Apelin-13水平均低于对照组(P均0.05)。病例组入院第1、7、14天血清Apelin-13水平与NIHSS评分均呈负相关关系(r分别为0.713、-0.596、-0.607,P均0.05)。随访3个月,病例组非残疾者97例、残疾者53例。病例组中,非残疾者入院第1、7、14天血清Apelin-13水平分别为(0.43±0.09)、(0.59±0.15)、(0.79±0.08)ng/m L,残疾者分别为(0.34±0.07)、(0.56±0.05)、(0.74±0.11)ng/m L;非残疾者入院第1、7、14天血清Apelin-13水平均高于入院同时间的残疾者(P均0.05)。结论急性缺血性脑卒中患者血清Apelin-13水平降低,且预后差者血清Apelin-13水平更低;Apelin-13水平与NIHSS评分呈负相关;血清Apelin-13检测可能有助于急性缺血性脑卒中患者病情及预后评估。
[Abstract]:Objective to observe the changes of serum Apelin-13 level in acute ischemic stroke and to explore its clinical significance.Methods 150 patients with acute ischemic stroke were selected as case group and 80 volunteers as control group.In the case group, Apelin-13 was detected by ELISA method on the 7th day after admission, and in the control group on the day of physical examination.The patients in the first day of admission were assessed with the National Institutes of Health Stroke scale (NIHSS) and the correlation between serum Apelin-13 level and NIHSS score was analyzed.The patients were followed up for 3 months to evaluate the short-term prognosis according to the modified Rankin scale (mRSv) and to compare the serum Apelin-13 levels of patients with different prognosis (disability and non-disability).The serum Apelin-13 level in the case group was lower than that in the control group (P < 0.05) on the 7th day after admission.There was a negative correlation between serum Apelin-13 level and NIHSS score on the 7th day after admission in the case group (r = 0.713 ~ (-0.596) ~ 0.607) (P = 0.05).Follow-up for 3 months revealed 97 cases of non-disabled and 53 cases of disability in the case group.Conclusion the level of serum Apelin-13 in patients with acute ischemic stroke is lower than that in patients with poor prognosis, and the level of Apelin-13 is negatively correlated with the NIHSS score, and the detection of serum Apelin-13 may be helpful to evaluate the condition and prognosis of patients with acute ischemic stroke.
【作者单位】：延安大学咸阳医院;
【分类号】：R743.3

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