灯盏细辛注射液联合胞磷胆碱钠胶囊治疗脑梗死的临床研究

发布时间：2018-04-11 18:29

本文选题：灯盏细辛注射液 + 胞磷胆碱钠胶囊　；参考：《现代药物与临床》2016年01期

【摘要】：目的研究灯盏细辛注射液联合胞磷胆碱钠胶囊治疗脑梗死患者的临床疗效。方法 2012年1月—2015年2月北京市东城区第一人民医院神经内科收治的脑梗死患者84例,随机分为对照组和治疗组,每组各42例。对照组在常规治疗的基础上口服胞磷胆碱钠胶囊,0.2 g/次,3次/d。治疗组在对照组治疗基础上静脉滴注灯盏细辛注射液,40 m L加入0.9%生理盐水250 m L中,1次/d。两组患者的治疗时间均为14 d。观察两组的临床疗效,同时比较两组治疗前后超氧化物岐化酶(SOD)、血清超敏C反应蛋白(CRP)、神经功能缺损程度(NIHSS)评分、Barthel指数、血浆黏度、全血黏度、纤维蛋白原、血小板聚集率、红细胞压积的变化情况。结果治疗后,对照组和治疗组的总有效率分别为61.90%、83.33%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者CRP、NIHSS评分、血浆黏度、全血黏度、纤维蛋白原、血小板聚集率、红细胞压积均显著降低,SOD、Barthel指数均显著升高,同组治疗前后差异具有统计学意义(P0.05);且治疗组这些观察指标的改善程度优于对照组,两组比较差异具有统计学意义(P0.05)。结论灯盏细辛注射液联合胞磷胆碱钠胶囊治疗脑梗死具有较好的临床疗效,有利于患者神经功能的恢复,改善生活能力,具有较好的临床使用价值。
[Abstract]:Objective to study the clinical effect of Fleabane Injection Combined with Citicoline Sodium Capsules treatment in patients with cerebral infarction. Methods from January 2012 to February 2015 in Beijing city of Dongcheng District first people's Hospital, Department of Neurology, 84 cases of cerebral infarction patients, were randomly divided into control group and treatment group, 42 cases in each group. The control group was treated in the conventional treatment based on the Citicoline Sodium Capsules 0.2, g/, 3 /d. treatment group in the control group based on the treatment of intravenous injection of erigeron injection, 40 m L in 0.9% ns 250 m L, 1 /d., two groups of patients with treatment time was 14 d. The clinical curative effect of two groups before and after treatment between the two groups at the same time, superoxide dismutase (SOD), serum high sensitivity C reactive protein (CRP), degree of neurological deficit (NIHSS) score, Barthel index, plasma viscosity, whole blood viscosity, fibrinogen, platelet aggregation rate, changes in hematocrit 2. Results after treatment, the treatment group and the control group the total effective rate was 61.90%, 83.33%, there was significant difference between two groups (P0.05). After treatment, two patients in the CRP group, NIHSS score, plasma viscosity, whole blood viscosity, fibrinogen, platelet aggregation rate, hematocrit decreased significantly, SOD, Barthel index were significantly higher, statistically significant differences in the same group before and after treatment and the treatment group (P0.05); these indicators were much better than the control group, with significant differences between the two groups (P0.05). Conclusion fleabane injection combined with Citicoline Sodium Capsules for the treatment of cerebral infarction has good clinical curative effect, is beneficial to patients the recovery of neurological function, improve the living ability, has good clinical value.

【作者单位】：北京市东城区第一人民医院神经内科;中国中医科学院西苑医院综合内科;
【分类号】：R743.33

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