同型半胱氨酸、糖化血红蛋白与急性缺血性脑卒中神经功能及远期预后的相关性研究

发布时间：2018-04-13 07:27

本文选题：急性缺血性脑卒中 + 同型半胱氨酸　；参考：《医学综述》2016年22期

【摘要】：目的探讨同型半胱氨酸(Hcy)、糖化血红蛋白(Hb A1c)与急性缺血性脑卒中神经功能及远期预后的相关性。方法选择2012年8月至2015年3月南充市第二人民医院收治的急性缺血性脑卒中患者98例,按照神经功能缺损评分(NIHSS)分为轻度组(NIHSS≤3分)27例、中度组(NIHSS4~15分)39例和重度组(NIHSS15分)32例,患者进行1年随访,采用改良Rankin量表(mRS)评价患者远期预后;检测各组患者Hcy、Hb A1c水平。结果中度组、重度组Hcy、Hb A1c水平均显著高于轻度组[(19.2±2.1)μmol/L、(35.4±4.8)μmol/L比(15.3±1.6)μmol/L,(6.4±0.7)%、(8.1±0.9)%比(5.8±0.5)%],其中重度组Hcy、Hb A1c水平显著高于中度组,差异有统计学意义(P0.05)。98例急性缺血性脑卒中患者按照mRS量表分级将预后分为预后良好组(mRS 0~2分)53例和预后不佳组(mRS 3~5分)45例;其中预后不佳组Hcy、Hb A1c水平显著高于预后良好组[(26.9±4.7)μmol/L比(20.5±3.5)μmol/L,(7.4±1.1)%比(6.3±0.9)%],差异有统计学意义(P0.01)。相关性分析显示,急性缺血性脑卒中患者Hcy、Hb A1c与NIHSS评分呈正相关(r=0.475,0.573,P0.05);Hcy、Hb A1c亦与mRS评分呈正相关(r=0.836,0.496,P0.05)。结论急性缺血性脑卒中患者Hcy、Hb A1c与神经功能和远期预后呈正相关,Hcy、Hb A1c均亦可作为预测患者预后的指标之一。
[Abstract]:Objective to investigate the relationship between Hcy, HbA1c, HbA1c and neurological function and long-term prognosis of acute ischemic stroke.Methods from August 2012 to March 2015, 98 patients with acute ischemic stroke admitted in Nanchong second people's Hospital were divided into mild group (27 cases), moderate group (39 cases) and severe group (32 cases).The patients were followed up for 1 year, the long-term prognosis was evaluated by modified Rankin scale mRSs, and the level of Hcyn HbA1c was measured.According to the mRS scale, the prognosis of 98 patients with acute ischemic stroke was divided into good prognosis group (53 cases) and poor prognosis group (45 cases).The level of Hcyn HbA1c in poor prognosis group was significantly higher than that in good prognosis group [26.9 卤4.7) 渭 mol / L vs 20.5 卤3.5 渭 mol / L, 7.4 卤1.1% vs 6.3 卤0.9%]. The difference was statistically significant (P 0.01).The correlation analysis showed that there was a positive correlation between Hcyn HB A1c and NIHSS score in patients with acute ischemic stroke. There was also a positive correlation between Hcyn HbA1c and mRS score.Conclusion there is a positive correlation between Hcyn HbA1c and neurological function and long-term prognosis in patients with acute ischemic stroke. Hcyn HbA1c can also be used as a predictor of prognosis in patients with acute ischemic stroke.
【作者单位】：南充市第二人民医院检验科;
【分类号】：R743.3;R446.1

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