缺血性脑卒中患者外周血血管内皮祖细胞水平变化及意义

发布时间：2018-04-16 07:04

本文选题：缺血性脑卒中 + 血管内皮祖细胞　；参考：《山东医药》2017年37期

【摘要】：目的探讨缺血性脑卒中患者外周血血管内皮祖细胞(EPCs)水平的变化及意义。方法选择缺血性脑卒中患者63例作为健康观察组、体检健康者20例作为健康对照组。分别于患者发病第1、7、14、21天用流式细胞术检测外周血EPCs比例,用酶联免疫吸附法检测血清血管内皮生长因子(VEGF)、基质细胞衍生因子1(SDF-1)水平。结果发病第1、7、14天,观察组外周血EPCs比例较健康对照组高(P均0.05),发病第21天两组外周血EPCs比例比较差异无统计学意义(P0.05)。发病第1、7、14天,观察组血清VEGF、SDF-1水平与对照组比较差异有统计学意义(P均0.05),发病第21天两组血清VEGF、SDF-1水平比较差异无统计学意义(P均0.05)。结论缺血性脑卒中患者发病第1天外周血EPGs数量减少,随后逐渐增多,至第21天恢复正常;EPGs数量变化可反映缺血性脑卒中患者病情发展。
[Abstract]:Objective to investigate the changes and significance of EPCs in peripheral blood vascular endothelial progenitor cells (EPCs) in patients with ischemic stroke.Methods 63 patients with ischemic stroke were selected as health observation group and 20 healthy persons as healthy control group.The proportion of EPCs in peripheral blood was detected by flow cytometry, and the levels of vascular endothelial growth factor (VEGF) and stromal cell derived factor 1 (SDF-1) were detected by enzyme-linked immunosorbent assay (Elisa).Results the proportion of EPCs in peripheral blood of the observation group was higher than that of the healthy control group (P < 0.05), but there was no significant difference in the proportion of peripheral blood EPCs between the two groups on the 21st day after the onset of the disease (P 0.05).On the 14th day after onset, the serum levels of VEGF SDF-1 in the observation group were significantly different from those in the control group (P < 0.05), but there was no significant difference between the two groups on the 21st day after the onset of the disease (P < 0.05).Conclusion the number of EPGs in peripheral blood of ischemic stroke patients decreased on the first day and then increased gradually, and the change of the number of EPGs could reflect the development of ischemic stroke patients by the 21st day.
【作者单位】：上海市杨浦区中心医院;
【基金】：上海市杨浦区卫生与计划生育委员会课题(201308)
【分类号】：R743.3

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