偏头痛脑白质高信号与临床特征及右向左分流的相关分析

发布时间：2018-04-16 08:01

本文选题：偏头痛 + 脑白质高信号　；参考：《临床神经病学杂志》2017年03期

【摘要】：目的从临床特征角度探索偏头痛脑白质高信号(WMHs)的危险因素,并研究右向左分流(RLS)是否与偏头痛WMHs有关。方法纳入偏头痛患者,采集头痛资料,进行对比增强TCD检查是否存在RLS以及分流量大小,并行头颅MRI检查评估WMHs。结果共纳入57例偏头痛患者,其中合并WMHs共18例(31.6%),主要位于额、顶叶,病变程度较轻。在对年龄、性别、头痛特征、焦虑抑郁评分以及RLS等因素的分析中,发现合并WMHs组与不合并WMHs组之间,仅年龄(P=0.002)、病程(P=0.046)存在统计学差异。结论偏头痛患者中发现的WMHs,主要位于额、顶叶,年龄、病程可能是其危险因素,未发现先兆、发作频率、持续时间、疼痛程度、焦虑抑郁等临床特征与其相关,也未发现RLS会增加偏头痛患者WMHs的风险。
[Abstract]:Objective to explore the risk factors of high signal intensity in the white matter of migraine and to study whether right to left shunt (RLS) is related to migraine WMHs.Methods the migraine patients were included in the study. Headache data were collected and contrast-enhanced TCD was performed to detect the presence of RLS and the flow rate. The head MRI was used to evaluate the presence of RLS.Results A total of 57 patients with migraine were included, of whom 18 cases were associated with WMHs, mainly located in the frontal and parietal lobes.In the analysis of age, sex, headache, anxiety and depression score and RLS, it was found that there was a statistical difference between the WMHs group and the WMHs group only in age (P < 0.002), course of disease (P = 0.046).Conclusion WMHs, mainly located in frontal, parietal lobe, age and course of disease, may be the risk factors in migraine patients. The clinical features of WMHs, such as symptoms, attack frequency, duration of onset, pain degree, anxiety and depression, are not associated with WMHs in migraine patients.Nor was RLS found to increase the risk of WMHs in migraine patients.
【作者单位】：西安交通大学第一附属医院神经内科;陕西省人民医院神经内科;西安交通大学第一附属医院影像科;
【基金】：国家十二五科技支撑计划(2014BAI04B05)
【分类号】：R747.2

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