T2WI直方图鉴别诊断脑胶质母细胞瘤与单发转移瘤的价值

发布时间：2018-04-17 23:28

本文选题：磁共振成像 + 直方图　；参考：《中国医学影像技术》2017年12期

【摘要】：目的探讨T2WI直方图鉴别诊断胶质母细胞瘤(GBM)与单发转移瘤瘤体中的价值。方法回顾性分析经手术病理确诊的GBM和单发转移瘤患者103例,其中GBM组57例,单发转移瘤组46例。所有患者术前均接受MR检查(T1WI、T2WI、T2-FLAIR和增强后T1WI)。采用Image J软件于肿瘤最大层面手动勾画瘤体边界,计算直方图相关参数,包括均数、标准差、中位数、峰度值和偏度值。采用独立样本t检验比较GBM与脑单发转移瘤的直方图各参数,评价差异有统计学意义参数的诊断效能。结果 GBM组的均数、标准差及中位数均高于单发转移瘤组,差异有统计学意义(P均0.05)。均数、标准差及中位数的ROC曲线下面积分别为0.772[95%CI(0.681,0.862),P0.001]、0.719[95%CI(0.616,0.822),P0.001]和0.767[95%CI(0.674,0.860),P0.001]。以均数临界值为509.575,鉴别两种病变的敏感度为0.719,特异度为0.783;以标准差临界值为58.844,鉴别两种病变的敏感度为0.702,特异度为0.652;以中位数临界值为550.500,鉴别两种病变的敏感度为0.719,特异度为0.826。结论肿瘤瘤体T2WI直方图均数、标准差和中位数均可用于GBM和脑单发转移瘤的鉴别,其中以均数的鉴别诊断效能最佳。
[Abstract]:Objective to evaluate the value of T2WI histogram in differential diagnosis of glioblastoma and single metastatic tumor.Methods 103 cases of GBM and single metastatic tumor confirmed by operation and pathology were analyzed retrospectively, including 57 cases in GBM group and 46 cases in single metastatic tumor group.All the patients underwent Mr examination before operation and T _ 1 WIN T _ 2 WI _ 2 flair and T _ 1WI _ 2 after enhancement.Image J software was used to manually draw the boundary of the tumor at the maximum level of the tumor, and the histogram parameters were calculated, including mean, standard deviation, median, kurtosis and bias.The histogram parameters of GBM and single brain metastases were compared by t-test of independent samples to evaluate the diagnostic effectiveness of the different parameters.Results the mean, standard deviation and median of GBM group were higher than those of single metastatic tumor group (P < 0.05).The area under the ROC curve of mean, standard deviation and median were 0.772 [95CII 0.681U 0.862 / P0.001] 0.719 [95CII 0.6160.2222 / P0.001] and 0.767 [95CI0.6740.6740.8660P0.001] respectively.The critical value of mean value was 509.575, the sensitivity and specificity of the two lesions were 0.719 and 0.778 3, the critical value of standard deviation was 58.844, the sensitivity and specificity of the two lesions were 0.702 and 0.652, and the median critical value was 550.500, and the sensitivity and specificity of the two lesions were 0.719 and 0.826 respectively.Conclusion the mean, standard deviation and median of T2WI histogram can be used in the differential diagnosis of GBM and single metastatic brain tumors, among which the mean value is the best in differential diagnosis.
【作者单位】：广州医科大学附属市一人民医院放射科;
【基金】：国家自然科学基金青年科学基金项目(81601469)
【分类号】：R445.2;R739.41

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