水通道蛋白-4在突触可塑性及学习记忆中的作用

发布时间：2018-04-18 23:35

本文选题：水通道蛋白- + 海马区　；参考：《生理学报》2017年03期

【摘要】：水通道蛋白-4(aquaporin-4,AQP-4)作为水通道蛋白家族之一,在中枢神经系统具有广泛的分布,且在星形胶质细胞终足上高表达。研究表明,AQP-4可通过调节星形胶质细胞的功能在维持脑内水稳态、脑体积和神经元兴奋性等方面发挥重要的作用。但是AQP-4在突触可塑性、学习记忆及认知等方面所发挥的作用还不明了。突触功能可塑性的变化按其性质的不同可分为长时程增强(long term potentiation,LTP)和长时程抑制(long term depression,LTD),两者被公认为是学习记忆的神经生物学基础。海马区是调节学习记忆过程的核心脑区,其突触可塑性与学习记忆有密切的关系。本文旨在综述AQP-4与海马区突触可塑性及相关学习记忆的关系研究进展,并展望AQP-4作为新的靶点在认知功能障碍中的可能作用,为临床治疗相关神经系统疾病提供新的思路与方向。
[Abstract]:Aquaporin -4 (aquaporin-4, AQP-4) as one of the water channel protein family, is widely distributed in the central nervous system, and is highly expressed in astrocytes. Studies show that AQP-4 can regulate the function of astrocytes in maintaining the brain water homeostasis, play an important role in brain volume and neuronal excitability etc. but AQP-4 in synaptic plasticity, learning and memory and cognitive play role is unclear. Synaptic plasticity changes according to the different nature can be divided into long term potentiation (long term, potentiation, LTP) and long term depression (long term, depression, LTD), both of which are recognized as the neurobiological basis of learning and memory. The hippocampus is the key brain regions regulating the process of learning and memory, synaptic plasticity and learning and memory are closely related. The purpose of this paper is to review its synaptic AQP-4 and sea can The research progress of the relationship between plastic and related learning and memory, and the prospect of AQP-4 may function as a new target in cognitive dysfunction, to provide new ideas and direction for the treatment of diseases of the nervous system.

【作者单位】：河南中医药大学基础医学院生理学学科;
【基金】：supported by the National Natural Science Foundation of China(No. 81373852) the Key Scientific Research Project of Colleges and Universities in Henan Province,China(No. 15A310019) PhD Research Fund of Henan University of Chinese Medicine,China (No. BSJJ-201510)
【分类号】：R741

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