血脂、血清β-AP和尿酸水平与急性脑梗死患者脑内微出血及预后的关系

发布时间：2018-04-19 12:32

本文选题：脑梗死 + 血脂　；参考：《山东医药》2017年11期

【摘要】：目的探讨血脂、血清β-淀粉样蛋白(β-AP)及尿酸水平与急性脑梗死患者脑内微出血和预后的关系。方法收集168例急性脑梗死患者的临床资料。比较有、无脑内微出血者,轻、中、重度脑内微出血者,预后良好、不良者的血清TC、TG、LDL-C、HDL-C、β-AP、尿酸,用Pearson法分析急性脑梗死血清TC、TG、LDL-C、HDL-C、β-AP、尿酸与脑内微出血发生、严重程度和预后的相关性。结果血清TC、TG、LDL-C、β-AP和尿酸水平有脑内微出血者高于无脑内微出血者,重度脑内微出血者高于中度脑内微出血者,中度脑内微出血者高于轻度脑内微出血者,预后不良者高于预后良好者,P均0.05;血清HDL-C水平有脑内微出血者低于无脑内微出血者,重度脑内微出血者低于中度脑内微出血者,中度脑内微出血者低于轻度脑内微出血者,预后不良者低于预后良好者,P均0.05。Pearson分析结果显示急性脑梗死患者血清TC、TG、LDL-C、β-AP和尿酸水平与脑内微出血发生、严重程度和预后不良呈正相关,血清HDL-C与脑内微出血发生、严重程度和预后不良呈负相关,P均0.05。结论血脂、血清β-AP及尿酸水平与急性脑梗死患者脑内微出血发生、严重程度和预后密切相关。血脂、血清β-AP及尿酸可能是预测急性脑梗死患者脑内微出血的发生、严重程度及预后的有用指标。
[Abstract]:Objective to investigate the relationship between serum lipids, serum 尾 -amyloid protein (尾 -APL) and uric acid levels and intracerebral microhemorrhage and prognosis in patients with acute cerebral infarction.Methods the clinical data of 168 patients with acute cerebral infarction were collected.The prognosis was good in the patients without intracerebral microhemorrhage, mild, moderate and severe intracerebral microhemorrhage. The serum TCG-TGG LDL-C, 尾 -APand uric acid were measured by Pearson method in patients with acute cerebral infarction. The correlation between TCG-TGG LDL-C, 尾 -APand uric acid and the occurrence, severity and prognosis of intracerebral microhemorrhage was analyzed by Pearson method.Results the levels of LDL-C, 尾 -AP and uric acid in serum TCU were higher in patients with intracerebral microhemorrhage than in those without intracerebral microhemorrhage, and in patients with severe intracerebral microhemorrhage were higher than those with moderate intracerebral microhemorrhage, and those with moderate intracerebral microhemorrhage were higher than those with mild intracerebral microhemorrhage.The levels of serum HDL-C in patients with intracerebral microhemorrhage were lower than those with anencephalic microhemorrhage, while those with severe intracerebral microhemorrhage were lower than those with moderate intracerebral microhemorrhage, and those with moderate intracerebral microhemorrhage were lower than those with mild intracerebral microhemorrhage.The results of 0.05.Pearson analysis showed that the levels of serum TCU TGG LDL-C, 尾 -AP and uric acid in patients with acute cerebral infarction were positively correlated with the occurrence of intracerebral microhemorrhage, and the severity was positively correlated with the poor prognosis, and serum HDL-C was associated with the occurrence of intracerebral microhemorrhage.There was a negative correlation between severity and poor prognosis (P < 0.05).Conclusion Serum lipids, serum 尾 -AP and uric acid levels are closely related to the occurrence, severity and prognosis of intracerebral microhemorrhage in patients with acute cerebral infarction.Serum lipids, serum 尾 -AP and uric acid may be useful indicators to predict the occurrence, severity and prognosis of intracerebral microhemorrhage in patients with acute cerebral infarction.
【作者单位】：佛山市顺德区第一人民医院;
【基金】：广东省医学科技发展计划项目(2015613)
【分类号】：R743.33

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