自身免疫性脑炎14例临床特点分析

发布时间：2018-04-20 11:09

本文选题：脑炎 + 自身免疫　；参考：《中国神经精神疾病杂志》2017年08期

【摘要】：目的探讨自身免疫性脑炎的临床特点以及不同的肿瘤干预方法对预后可能的影响。方法纳入自身免疫性脑炎患者14例,分析其临床症状、辅助检查结果、合并肿瘤情况、治疗方案,并利用改良Rankin量表(modified Rankin Scale,mRS)对其神经功能进行评价。结果男女比例为1:1.8,平均发病年龄38.4±18.3岁,呈急性或亚急性起病,临床症状主要为癫痫、精神异常、记忆力减退及反应迟钝,其中3例患者合并肿瘤。大部分患者均接受了糖皮质激素及免疫球蛋白治疗,接受免疫治疗后,患者的m RS较前改善(P0.001)。结论早期免疫治疗对自身免疫性脑炎总体效果良好,但治疗总疗程目前暂不明确,如发现合并肿瘤,及时干预对预后可能有所帮助。
[Abstract]:Objective to investigate the clinical features of autoimmune encephalitis and the possible influence of different tumor intervention methods on prognosis. Methods 14 patients with autoimmune encephalitis were included. Their clinical symptoms, adjuvant examination results, combined tumor status, treatment plan were analyzed, and their neurological function was evaluated by modified Rankin Scalem RSs. Results the ratio of male to female was 1: 1.8. The average age of onset was 38.4 卤18.3 years old. The main clinical symptoms were epilepsy, mental disorder, memory loss and slow reaction. Most of the patients received glucocorticoid and immunoglobulin therapy. Conclusion the overall effect of early immunotherapy on autoimmune encephalitis is good, but the total course of treatment is not clear at present. If the tumor is found, timely intervention may be helpful to the prognosis.
【作者单位】：福建医科大学附属第一医院神经内科;福建医科大学附属第一医院康复科;
【基金】：国家临床重点专科建设项目经费资助(编号:2012-GJCZD)
【分类号】：R742.9

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