Framelink手术规划结合微电极电生理监测在DBS治疗帕金森病中的应用

发布时间：2018-04-22 02:18

本文选题：帕金森病 + 脑深部电刺激　；参考：《中国微侵袭神经外科杂志》2016年01期

【摘要】：目的探讨Framelink手术计划系统结合微电极电生理监测技术在帕金森病脑深部电刺激术(DBS)中的临床应用。方法回顾性分析7例接受丘脑底核-脑深部电刺激(STN-DBS)治疗的帕金森病人的临床资料。术前应用Framelink手术计划系统行STN靶点定位,术中采用Lead-Point微电极记录细胞外放电进行STN验证和电刺激,观察病人症状改善及不良反应发生情况。比较影像解剖STN与功能STN核团长度。结果 Framelink手术计划系统的应用,使术中STN核清晰可见。共植入电极9根(左侧3根,右侧6根),其中8根(88.9%)微电极一次成功定位。共用MER针道10道,每植入1根电极平均需要1.1针道,针道更换率为11%。术后颅脑CT证实,电极位置满意100%,无颅内血肿发生。影像解剖STN核与功能STN核长度无明显差异(P0.05)。结论 Framelink手术计划系统结合微电极电生理监测技术可提高脑深部电极植入靶点的准确性,减少穿刺次数,降低手术并发症,提高手术疗效。
[Abstract]:Objective to investigate the clinical application of Framelink surgical planning system combined with microelectrode electrophysiological monitoring in patients with Parkinson's disease. Methods the clinical data of 7 patients with Parkinson's disease treated with STN DBS were retrospectively analyzed. Preoperative Framelink operation planning system was used to locate STN targets, and Lead-Point microelectrode was used to record extracellular discharges for STN verification and electrical stimulation during the operation. The improvement of symptoms and adverse reactions were observed. The length of STN and functional STN were compared. Results with the application of Framelink operation planning system, the nucleus of STN was clearly visible during operation. A total of 9 implanted electrodes (3 on the left and 6 on the right) were successfully located at one time. There are 10 common MER needle paths, and an average of 1. 1 needle path is required for each electrode implanted, and the needle replacement rate is 11. After operation, the brain CT confirmed that the electrode position was satisfactory and there was no intracranial hematoma. There was no significant difference in length between STN nucleus and functional STN nucleus in imaging anatomy (P 0.05). Conclusion Framelink operation planning system combined with microelectrode electrophysiological monitoring technique can improve the accuracy of deep brain electrode implantation target, reduce the number of puncture, reduce the complications of surgery, and improve the curative effect.
【作者单位】：宁夏医科大学总医院神经外科宁夏颅脑疾病重点实验室;解放军93868部队医院内科;宁夏医科大学总医院放射科;
【分类号】：R742.5

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