脑脊液置换联合鞘内注射治疗结核性脑膜炎临床疗效评价

发布时间：2018-04-22 03:38

本文选题：结核性脑膜炎 + 脑脊液置换　；参考：《中国实用神经疾病杂志》2014年20期

【摘要】：目的评估脑脊液置换联合鞘内注射治疗结核性脑膜炎的临床效果。方法结脑患者64例随机分为对照组32例和观察组32例。对照组予以异烟肼、利福平、吡嗪酰胺、乙胺丁醇等抗结核治疗及地塞米松激素治疗。观察组在常规抗结核治疗的基础上加用脑脊液置换联合鞘内注入异烟肼,地塞米松,胞二磷胆碱等药物治疗。分别记录2组脑脊液转阴时间,临床症状消失时间,住院时间,观察周期3个月,比较2组疗效。结果观察组总有效率脑脊液转阴时间、临床症状消失时间、住院时间方面均明显优于对照组(P0.05)。结论脑脊液置换联合鞘内注射治疗结核性脑膜炎可有效缓解结核性脑膜炎患者的临床症状,缩短疗程,临床效果显著。
[Abstract]:Objective to evaluate the clinical effect of cerebrospinal fluid replacement combined with intrathecal injection in the treatment of tuberculous meningitis. Methods 64 patients were randomly divided into control group (n = 32) and observation group (n = 32). The control group was treated with isoniazid rifampicin pyrazinamide ethambutanol and dexamethasone. The treatment group was treated with cerebrospinal fluid replacement combined with intrathecal injection of isoniazid, dexamethasone and cytidine diphosphate choline on the basis of routine antituberculous therapy. The time of negative cerebrospinal fluid (CSF), the time of clinical symptom disappearance, the time of hospitalization, and the observation period of 3 months were recorded, and the curative effect of the two groups was compared. Results the total effective time of cerebrospinal fluid turning negative, the time of clinical symptom disappearance and the time of hospitalization in the observation group were significantly better than those in the control group (P 0.05). Conclusion Cerebrospinal fluid replacement combined with intrathecal injection in the treatment of tuberculous meningitis can effectively relieve the clinical symptoms of patients with tuberculous meningitis and shorten the course of treatment.
【作者单位】：郑州大学第一附属医院感染科;
【分类号】：R529.3

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