血浆和肽素与高敏C反应蛋白在脑梗死病情评估中的应用

发布时间：2018-04-22 20:39

本文选题：和肽素 + 高敏C反应蛋白　；参考：《广东医学》2017年23期

【摘要】：目的探讨血浆和肽素(Copeptin)和高敏C反应蛋白(hs-CRP)在脑梗死病情评估中的应用。方法选取脑梗死患者83例为脑梗死组,入院时采用酶联免疫吸附试验(ELLSA)法检测患者血浆中Copeptin和hs-CRP浓度,并选取同期健康体检者30例作为对照组,随访6个月后采用Rankin量表(mRS)评分进行预后评估。结果脑梗死组血浆Copeptin和hs-CRP水平明显高于对照组,差异有统计学意义(P0.05);预后良好组的血浆Copeptin和hs-CRP水平明显低于预后不良组,且由Spearman相关性分析结果显示,脑梗死患者血浆Copeptin和hs-CRP水平与预后呈正相关(P0.05);ROC分析显示,联合检测血浆中Copeptin和hs-CRP水平对预后的评估的价值明显高于单独检测,差异有统计学意义(P0.05)。结论入院时检测脑梗死患者血浆中Copeptin和hs-CRP水平可作为预后评估的参考依据之一。
[Abstract]:Objective to investigate the application of plasma and peptide Copeptin and Gao Min C-reactive protein hs-CRP in the assessment of cerebral infarction. Methods Eighty-three patients with cerebral infarction were selected as cerebral infarction group. The plasma Copeptin and hs-CRP levels were detected by Elisa on admission, and 30 healthy controls were selected as control group. After 6 months follow-up, the prognosis was evaluated with Rankin scale mRS. Results the plasma Copeptin and hs-CRP levels in cerebral infarction group were significantly higher than those in control group (P 0.05), the plasma Copeptin and hs-CRP levels in good prognosis group were significantly lower than those in poor prognosis group, and the results of Spearman correlation analysis showed that there was no significant difference between the two groups. Plasma Copeptin and hs-CRP levels in patients with cerebral infarction were positively correlated with prognosis (P 0.05). The value of combined detection of Copeptin and hs-CRP in evaluating prognosis was significantly higher than that in patients with cerebral infarction (P 0.05). Conclusion determination of plasma Copeptin and hs-CRP levels in patients with cerebral infarction at admission can be used as a reference for prognostic evaluation.
【作者单位】：萍乡市人民医院神经内科;
【分类号】：R743.33

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