营养代谢指标在脑卒中的变化研究

发布时间：2018-04-23 21:17

本文选题：脑卒中 + 超敏C反应蛋白　；参考：《浙江大学》2014年硕士论文

【摘要】：目的：研究营养代谢指标在脑卒中患者疾病进展中的变化规律。方法：纳入发病48小时内住院的脑卒中患者80例,其中脑梗塞50例,脑出血30例。用美国国立卫生研究院卒中量表(National Institute of Health stroke scale, NIHSS)评估入院时卒中严重程度。入院第1天、第7天、第14天、第30天分别监测患者营养代谢状况指标。检测内容包括物理测量和实验室检验。物理测量指标包括体重、体重指数、三头肌皮褶厚度、上臂围和上臂肌围。实验室指标包括超敏C-反应蛋白(超敏CRP)、补体C3、前白蛋白和皮质醇水平。结果：入院后患者的物理测量指标无明显变化。入院后各化验指标出现明显的变化,入院第7天患者前白蛋白和补体C3水平较入院第1天明显下降(P0.05),超敏CRP和皮质醇水平明显上升(P0.05)。入院第14天,超敏CRP和皮质醇水平仍明显高于入院第1天(P0.05),但较入院第7天有所恢复,前白蛋白和补体C3水平与入院第1天无统计学差异。疾病进程第30天各指标基本恢复基线水平。NIHSS分值与营养代谢指标紊乱严重程度相关。脑梗塞患者与脑出血患者的各指标曲线无明显差异。结论：物理指标变化无法客观反应脑卒中进程中营养状态的改变,超敏c-反应蛋白(超敏CRP)、补体C3、前白蛋白和皮质醇水平在脑卒中过程中呈现明显的时间相关性,在发病的急性期变化最为明显,提示在脑卒中急性期存在明显的营养代谢紊乱,并且代谢紊乱程度与入院卒中严重程度相关。
[Abstract]:Objective: to study the changes of nutritional metabolism indexes in stroke patients. Methods: a total of 80 stroke patients, including 50 cases of cerebral infarction and 30 cases of intracerebral hemorrhage, were included in the study. The National Institute of Health stroke scale (NIHSS) was used to assess the severity of stroke at admission. The nutritional status of patients was monitored on day 1, day 7, day 14 and day 30. The tests include physical measurements and laboratory tests. Physical measurements include body weight, body mass index, triceps skinfold thickness, upper arm circumference and upper arm muscle circumference. Laboratory parameters include hypersensitive C-reactive protein (HCRP), complement C _ 3, prealbumin and cortisol levels. Results: there was no significant change in the physical parameters of the patients after admission. On the 7th day after admission, the levels of prealbumin and complement C3 decreased significantly compared with those on the first day of admission, and the levels of hypersensitive CRP and cortisol increased significantly. On the 14th day of admission, the levels of CRP and cortisol were still significantly higher than those on the first day of admission, but the levels of prealbumin and complement C3 were not significantly different from those of the first day of admission. On the 30th day of disease progression, the basic restoration of baseline level. NIHSS score was related to the severity of disturbance of nutritional metabolism index. There was no significant difference between cerebral infarction patients and cerebral hemorrhage patients. Conclusion: the changes of physical parameters can not objectively reflect the changes of nutritional status during stroke, and the levels of hypersensitive c-reactive protein (CRP), complement C _ 3, prealbumin and cortisol are significantly correlated in the course of stroke. The changes were most obvious in the acute stage of stroke, suggesting that there was a significant metabolic disorder in the acute phase of stroke, and the degree of metabolic disorder was related to the severity of stroke in hospital.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

【相似文献】