甘肃省脑卒中数据库的初步建立及应用

发布时间：2018-04-24 06:48

本文选题：脑卒中 + 高危人群　；参考：《兰州大学》2017年硕士论文

【摘要】：目的初步建立甘肃省脑卒中数据库,利用该数据库对脑卒中临床数据进行保存和管理。并对青年缺血性脑卒中的危险因素及病因分型特点进行初步探讨,探索数据库的应用价值。方法1通过了解国内外脑卒中疾病的研究现状和进展,并结合甘肃省各地脑卒中及其高危人群的区域性特征,制定初级字段,进而在结构化语言查询(My Structured Query Language,MySQL)数据库管理软件的模块下初步建立甘肃省脑卒中数据库。2利用初步建成的甘肃省脑卒中数据库对兰州大学第二医院神经内科部分缺血性脑卒中患者进行了预登记录入。根据纳入标准共纳入52例青年缺血性脑卒中患者和53例中老年缺血性脑卒中患者,将入组患者的病例资料导出并统计分析。进一步根据中国缺血性卒中亚型(Chinese Ischemic Stroke Subclassification,CISS)明确所有研究对象的病因分型,比较两组患者的病因分型及相关危险因素特点。结果1初步建立了甘肃省脑卒中数据库。该数据库包含了一般信息表、卒中地域表、卒中类型表、高危因素表、干预方式表和病例资料表。具有录入、查询、导入导出、数据备份及移植等功能。2青年缺血性脑卒中组52例,平均年龄(36.94±8.55)岁,男性43例(82.69%),女性9例(17.31%)。青年缺血性卒中组的危险因素排在前4位的分别是:男性82.7%,吸烟史53.8%,高血压病44.2%,高脂血症42.3%;中老年缺血性卒中组的危险因素排在前4位的依次为:男性73.6%,高血压病64.2%,高同型半胱氨酸血症41.5%,糖尿病28.3%。对两组间相关危险因素进行比较,高脂血症、高血压、饮酒、吸烟、卒中家族史和颅内、外动脉狭窄间比较差异具有显著性(P0.05)。青年组高脂血症、吸烟、饮酒、卒中家族史、颅内外动脉狭窄的比例明显高于中老年组,两组间差异具有显著性(P0.05);中老年组高血压患病率明显高于青年组,两组间差异具有显著性(P0.05)。同时,青年组CISS病因分型依次为大动脉粥样硬化(Large Artery Atherosclerosis,LAA)28.8%,其他病因(Other Etiology,OE)21.2%,穿支动脉疾病(Penetrating Artery Disease,PAD)19.2%,原因不明(Undetermined Etiology,UE)17.3%,心源性卒中(Cardiogenic Stroke,CS)13.5%。两组间除OE分型外,其余各分型间比较无统计学差异。中老年缺血性卒中组LAA、CS、PAD分型的比例均高于青年缺血性卒中组。青年缺血性卒中组OE、UE分型高于中老年缺血性卒中组。结论1甘肃省脑卒中数据库内容完整,结构设计合理,层次清晰,操作简单。该数据库在研究脑卒中病因、危险因素、流行病学及防治等应用方面具有重要的作用和意义。2青年缺血性卒中好发于男性。吸烟,高血压,高脂血症是最常见的危险因素。对这些危险因素实施具有针对性的预防治疗保健计划将会减少青年人群这个社会经济活跃年龄段人群的脑卒中发病率和死亡率。中国缺血性卒中亚型是进行基础研究和临床实践的关键,它对青年缺血性卒中病因的识别和预防的实施至关重要。
[Abstract]:Objective to establish a stroke database in Gansu province and use it to preserve and manage the clinical data of stroke. The risk factors and etiological classification characteristics of ischemic stroke in young people were preliminarily discussed, and the application value of database was explored. Methods 1 the primary field was established by understanding the current situation and progress of stroke disease research at home and abroad, and combining with the regional characteristics of stroke and its high risk population in Gansu Province. Furthermore, under the module of my Structured Query language (MySQL) database management software, the database .2 of Gansu Provincial Stroke Database. 2 was established by using the preliminary completed database of Gansu Provincial Stroke to the Department of Neurology, second Hospital of Lanzhou University. Ischemic stroke patients were pre-registered. According to the inclusion criteria, 52 young patients with ischemic stroke and 53 middle-aged and old patients with ischemic stroke were included. According to the Chinese Ischemic Stroke subclassification CISS, the etiological classification of all the subjects was determined, and the etiological classification and related risk factors of the two groups were compared. Results 1 A stroke database was established in Gansu Province. The database contains general information tables, stroke area tables, stroke type tables, risk factors tables, intervention patterns and case tables. There were 52 young patients with ischemic stroke with input, query, import and export, data backup and transplantation. The average age was 36.94 卤8.55 years old. There were 43 males (82.69%) and 9 females (17.31%). In the young ischemic stroke group, the risk factors were 82.7in male, 53.83.8in smoking history, 44.22um in hypertension, 42.3 in hyperlipidemia, and 73.6 in male in the middle and old age ischemic stroke group. Disease 64.2, hyperhomocysteinemia 41.5, diabetes 28.3. The relative risk factors of hyperlipidemia, hypertension, alcohol consumption, smoking, stroke family history, intracranial and external artery stenosis were significantly different between the two groups (P 0.05). The proportion of hyperlipidemia, smoking, drinking, family history of stroke and stenosis of extracranial artery in the young group was significantly higher than that in the middle and old age group (P 0.05), the prevalence of hypertension in the middle and old age group was significantly higher than that in the young group, the incidence of hypertension in the middle and old age group was significantly higher than that in the young group. There was significant difference between the two groups (P 0.05). At the same time, the etiological classification of CISS in the young group was as follows: large Artery Atherosclerosissis-LAA28.8B, other etiological factors other Etiology OE 21.2, perforating artery disease Penetrating Artery disease19.2, undetermined etiology 17.3, Cardiogenic Stroke-CS13.5T in patients with cardiogenic apoplexy. There was no statistical difference between the two groups except OE typing. The percentage of pad typing in middle and old patients with ischemic stroke was higher than that in young patients. The OEUE classification of ischemic stroke in young patients was higher than that in middle-aged patients with ischemic stroke. Conclusion 1 the stroke database in Gansu Province is complete in content, reasonable in structure, clear in level and simple in operation. This database plays an important role in studying the etiology, risk factors, epidemiology, prevention and treatment of stroke. Smoking, hypertension and hyperlipidemia are the most common risk factors. Targeted preventive treatment and health care programs for these risk factors will reduce stroke morbidity and mortality among young people of this socially active age group. The central type of ischemic stroke in China is the key to basic research and clinical practice. It is very important to identify and prevent the causes of ischemic stroke in young people.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.3

【相似文献】