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脑梗死血浆正五聚蛋白3的动态改变及与颈动脉不稳定斑块的关系

发布时间:2018-04-27 15:35

  本文选题:正五聚蛋白 + 脑卒中 ; 参考:《中国神经精神疾病杂志》2017年03期


【摘要】:目的研究急性缺血性脑卒中与血浆正五聚蛋白3(pentraxin 3,PTX3)水平的关系,并探索血浆PTX3水平与颈动脉粥样硬化的关系。方法纳入急性缺血性脑卒中患者共103例,对照组患者83例。应用酶联免疫吸附法(ELISA)检测所有患者入院时的血浆PTX3水平,以及急性缺血性脑卒中患者规律治疗第7天的血浆PTX3水平。对急性缺血性脑卒中患者进行颈部多普勒血管超声检查,根据颈动脉斑块稳定性将患者分为两组。研究血浆PTX3水平与急性缺血性脑卒中及颈部斑块稳定性之间的关系。结果 (1)急性缺血性脑卒中组的血浆PTX3水平明显高于对照组(P0.05),经规律治疗7 d后,恢复期的血浆PTX3水平明显低于急性期(P0.05),但仍高于对照组(P0.05)。经多因素Logistic回归后提示血浆PTX3水平与急性缺血性脑卒中密切相关(OR=15.043,95%CI:3.46~65.45,P0.001)。(2)急性缺血性脑卒中组中,不稳定斑块组急性期和恢复期的血浆PTX3水平均高于无斑块与稳定斑块组(P0.05)。结论急性缺血性脑卒中患者具有较高的血浆PTX3水平,伴有颈动脉不稳定斑块的急性缺血性脑卒中患者血浆PTX3水平更高。血浆PTX3水平与急性缺血性脑卒中密切相关。
[Abstract]:Objective to study the relationship between acute ischemic stroke and plasma normal pentagglutinin (3(pentraxin _ 3) PTX _ 3, and to explore the relationship between plasma PTX3 level and carotid atherosclerosis. Methods 103 patients with acute ischemic stroke and 83 patients with control group were included. The plasma PTX3 levels of all patients were measured by Elisa and the plasma PTX3 levels of patients with acute ischemic stroke were measured on the 7th day after regular treatment. The patients with acute ischemic stroke were divided into two groups according to the stability of carotid plaque. To study the relationship between plasma PTX3 level and the stability of acute ischemic stroke and cervical plaque. Results 1) the plasma PTX3 level in the acute ischemic stroke group was significantly higher than that in the control group (P 0.05). After regular treatment for 7 days, the plasma PTX3 level in the convalescent stage was significantly lower than that in the acute phase, but still higher than that in the control group. After multivariate Logistic regression, it was suggested that plasma PTX3 level was closely related to acute ischemic stroke. The plasma PTX3 level in acute ischemic stroke group was higher than that in unstable plaque group and stable plaque group (P 0.05). Conclusion the plasma PTX3 level in patients with acute ischemic stroke is higher than that in acute ischemic stroke patients with unstable plaque of carotid artery. Plasma PTX3 level is closely related to acute ischemic stroke.
【作者单位】: 中国医科大学附属盛京医院;
【分类号】:R743.33


本文编号:1811296

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