新生猪缺氧缺血脑损伤后酰胺质子转移成像

发布时间：2018-04-29 17:49

本文选题：脑损伤 + 缺氧缺血　；参考：《中国医学影像技术》2017年08期

【摘要】：目的探讨不同时间点新生猪缺氧缺血脑损伤(HIBI)模型酰胺质子转移(APT)成像基底核APT值的变化。方法选用出生后3~5天的健康新生猪35只,分为对照组(n=5)及模型组(n=30),分别进行假手术(对照组)及HIBI建模操作。其中模型组依据MR扫描和建立HIBI模型的间隔时间分为0~2h、2~6h、6~12h、12~24h、24~48h、48~72h亚组。对各组均行APT成像,测量双侧基底核APT值。比较对照组及模型组各亚组间基底核APT值的差异。结果新生猪HIBI后0~2h,APT值出现急剧下降,随后逐渐升高,24h左右基本恢复至对照组水平。对照组及模型组0~2h、2~6h、6~12h、12~24h、24~48h、48~72h亚组平均APT值分别为0.52±0.09、-0.35±0.08、-0.02±0.14、0.28±0.04、0.46±0.11、0.80±0.11、1.24±0.18。除12~24h亚组外(P=0.68),模型组其余各亚组与对照组间APT值差异均有统计学意义(P均0.01)。结论 APT值在新生猪HIBI后呈现先下降后上升的变化趋势,有望为今后进一步临床研究HIBI患儿脑内病理生理变化提供参考依据。
[Abstract]:Objective to investigate the changes of APT values in basal nucleus of neonatal pigs with hypoxic ischemic brain injury (HIBI) model at different time points. Methods Thirty-five healthy newborn pigs were divided into control group (control group) and model group (control group) and model group (control group) and HIBI modeling operation. The model group was divided into two groups according to Mr scanning and the interval time of HIBI model. APT imaging was performed in all groups, and the APT values of bilateral basal nuclei were measured. The APT values of basal nucleus were compared between the control group and the model group. Results APT decreased sharply at 0 ~ 2 h after HIBI, then gradually increased to the control level at about 24 h. The average APT values of the control group and the model group were 0.52 卤0.09h-0.35 卤0.08U -0.02 卤0.140.28 卤0.04U 0.46 卤0.111.80 卤0.111.24 卤0.111.24 h and 48h / 72 h, respectively, and the average APT values of the control group and the model group were 0.52 卤0.09 ~ 0.35 卤0.08U -0.02 卤0.140.28 卤0.04U 0.46 卤0.111.24 卤0.111.24 卤0.18, respectively. The APT values of the other subgroups in the model group were significantly different from those of the control group (P < 0.01) except for the control group (P < 0.01). Conclusion the value of APT in newborn pigs showed a tendency of decreasing first and then rising after HIBI, which may provide a reference for further clinical study on the changes of brain pathophysiology in children with HIBI.
【作者单位】：中国医科大学附属盛京医院放射科;
【基金】：国家自然科学基金(30570541、30770632、81271631) 盛京医院自由研究者基金(201402)
【分类号】：R445.2;R742

【相似文献】