脑靶向鼻黏膜给药系统用于神经退行性疾病治疗

发布时间：2018-04-30 01:02

本文选题：脑靶向 + 阿尔茨海默病　；参考：《国际药学研究杂志》2016年01期

【摘要】：随着老龄化社会的到来,神经退行性疾病的发病率逐年增加,严重影响患者生活质量。神经退行性疾病发生于中枢神经系统,其治疗药物的给药方式成为一个关键的科学问题。如果通过口服或注射途径给药,部分药物能经过血脑屏障进入脑组织,但大量药物在其他组织分布,可能带来胃肠道反应、心律失常等副作用;且老年患者服药顺应性差,不能坚持多次多剂量服用。鼻黏膜给药可绕开血脑屏障,通过鼻-脑通道直接将药物递送到脑组织,靶向性强,药物利用率高,患者顺应性好。本综述简要介绍了神经退行性疾病的主要类型及治疗现状,脑靶向递药的主要屏障、鼻-脑通道及影响经鼻吸收的主要因素,并总结了脑靶向鼻黏膜给药的主要剂型、最新进展及存在问题。
[Abstract]:With the coming of aging society, the incidence of neurodegenerative diseases increases year by year, which seriously affects the quality of life of patients. Neurodegenerative diseases occur in the central nervous system (CNS). If administered orally or by injection, some drugs can pass through the blood-brain barrier into the brain, but a large number of drugs are distributed in other tissues, which may bring side effects such as gastrointestinal reactions, arrhythmias, and poor drug compliance in elderly patients. Do not persist in multiple doses. Nasal mucosal administration can bypass the blood-brain barrier and deliver drugs directly to brain tissue through rhino-brain channels, with strong targeting, high drug utilization and good patient compliance. This review briefly introduces the main types and treatment status of neurodegenerative diseases, the main barrier of brain targeting drug delivery, rhino-brain channels and the main factors affecting nasal absorption, and summarizes the main dosage forms of brain targeted nasal mucosal administration. Latest progress and problems.
【作者单位】：军事医学科学院放射与辐射医学研究所;
【基金】：国家科技重大专项综合性新药研究开发技术大平台资助项目(2012ZX09301003-001-009)
【分类号】：R741

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