丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床研究

发布时间：2018-04-30 17:25

本文选题：丹参注射液 + 尼莫地平缓释片　；参考：《中国临床药理学杂志》2017年08期

【摘要】：目的观察丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床疗效及安全性。方法将106例新发高血压出血性脑卒中患者分为对照组64例和试验组42例。对照组予以吸氧、吸痰、控制脑水肿、维持电解质平衡、营养脑细胞等常规治疗;试验组在对照组治疗的基础上,予以丹参注射液10 mg·d~(-1),静脉滴注速度1 mg·h~(-1)+尼莫地平缓释片每次20 mg,tid,口服。2组患者均治疗14 d。比较2组患者的临床疗效、血肿吸收情况,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为95.24%(40/42例)和85.94%(55/64例),差异有统计学意义(P0.05)。治疗后第14,28天,试验组的平均血肿体积分别为(8.26±4.39),(6.76±3.16)mL,对照组的平均血肿体积分别为(12.41±5.02),(9.33±4.78)mL,差异均有统计学意义(均P0.05)。试验组的药物不良反应主要有头痛、胃肠道反应、低血压、血小板减少、皮肤刺痛,对照组的药物不良反应主要有头痛、胃肠道反应。试验组和对照组的药物不良反应发生率分别为19.04%(8/42例)和7.81%(5/64例),差异无统计学意义(P0.05)。结论丹参注射液联合尼莫地平缓释片治疗高血压出血性脑卒中的临床疗效肯定,能显著地促进血肿的吸收,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the efficacy and safety of salvia miltiorrhiza injection combined with nimodipine sustained-release tablet in the treatment of hypertensive hemorrhagic stroke. Methods 106 patients with newly developed hypertensive hemorrhagic stroke were divided into control group (n = 64) and experimental group (n = 42). The control group received routine treatment such as oxygen inhalation, sputum suction, brain edema control, electrolyte balance, nutrition brain cells, etc. The experimental group was treated on the basis of the control group. Salvia miltiorrhiza injection (10 mg / d) was given intravenously at a rate of 1 mg / h ~ (-1) nimodipine sustained release tablet (20 mg / d) for 14 days. The clinical efficacy, hematoma absorption and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the test group and the control group were 95.2440 / 42 and 85.94, 55 / 64, respectively. The difference was statistically significant (P 0.05). On the 28th day after treatment, the mean hematoma volume in the experimental group was 6.76 卤3.16mL, and the mean hematoma volume in the control group was 12.41 卤5.02 卤4.78mL, respectively. The difference was statistically significant (all P 0.05). The main adverse drug reactions in the trial group were headache, gastrointestinal reaction, hypotension, thrombocytopenia, prickly skin, and the main adverse drug reactions in the control group were headache and gastrointestinal reaction. The incidence of adverse drug reactions in the test group and the control group were 19.04 / 42 and 7.81 / 5 / 64, respectively. There was no significant difference between the two groups in the incidence of adverse drug reactions (P 0.05). Conclusion Salvia miltiorrhiza injection combined with nimodipine sustained-release tablet is effective in the treatment of hypertensive hemorrhagic stroke. It can significantly promote the absorption of hematoma and does not increase the incidence of adverse drug reactions.
【作者单位】：海口市人民医院神经内科;海南省农垦总局医院神经内科;
【基金】：海南省自然科学基金资助项目(30716)
【分类号】：R544.1;R743.3

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