OSAHS与脑卒中后患者认知障碍及功能状态的相关性研究

发布时间：2018-05-02 03:47

本文选题：睡眠呼吸暂停低通气综合征 + 阻塞性　；参考：《临床耳鼻咽喉头颈外科杂志》2017年13期

【摘要】：目的:分析OSAHS与脑卒后患者认知障碍及功能状态的相关性。方法:2014-02-2016-09期间共纳入189例符合研究标准的患者,剔除33例轻度OSAHS患者,86例研究组患者和70例对照组患者纳入最终分析。主要检测指标为认知状态和功能状态。认知状态由以下维度进行评估:警惕性、注意力、记忆力、工作记忆、执行力、语言、洞察力、精神活动、精神运动能力以及智力;利用神经状态和功能独立性评估功能状态。次要指标包括嗜睡、疲劳、焦虑和抑郁及睡眠质量。结果:研究组年龄大于对照组,BMI高于对照组,平均住院时间长于对照组,均差异有统计学意义(均P0.05)。2组总认知状态差异明显,研究组明显差于对照组(t=9.276,P=0.012)。研究组患者的注意力、执行力、洞察力、心理调节能力和智力均低于对照组,差异有统计学意义(均P0.05)。研究组较对照组患者的功能状态更差(t=38.094,P=0.000)。2组患者的次要指标包括嗜睡、疲劳、睡眠质量、焦虑和抑郁均差异无统计学意义(均P0.05)。结论:伴OSAHS的脑卒中患者认知障碍和功能状态明显更差,OSAHS是脑卒中患者预后不良的危险因素。
[Abstract]:Objective: to analyze the correlation between OSAHS and cognitive impairment and functional state of stroke patients. Methods between 2014-02-2016-09, 189 patients were included in the study group, 33 patients with mild OSAHS were excluded, 86 patients in the study group and 70 patients in the control group were included in the final analysis. The main indicators were cognitive state and functional state. Cognitive state was evaluated by the following dimensions: vigilance, attention, memory, working memory, executive ability, language, insight, mental activity, mental motor ability and intelligence; functional state was evaluated using neural state and functional independence. Secondary indicators include drowsiness, fatigue, anxiety and depression, and sleep quality. Results: the age of the study group was higher than that of the control group, and the average hospitalization time was longer than that of the control group. The difference was statistically significant (all P0.05T.2), the total cognitive state of the study group was significantly different, and the study group was significantly worse than the control group (9.276g / kg). The attention, executive ability, insight, psychological regulation ability and intelligence of the patients in the study group were lower than those in the control group (P 0.05). There was no significant difference in the secondary indexes including somnolence, fatigue, sleep quality, anxiety and depression between the study group and the control group (P 0.05). Conclusion: cognitive impairment and poor functional state of stroke patients with OSAHS are risk factors of poor prognosis.
【作者单位】：郑州人民医院神经内科五病区;
【分类号】：R743.3;R766

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