癫痫患者外周血免疫球蛋白、补体的变化及与癫痫严重程度的相关性研究

发布时间：2018-05-04 11:24

本文选题：癫痫 + 严重程度　；参考：《苏州大学》2014年硕士论文

【摘要】：目的：研究癫痫患者外周血免疫球蛋白、补体的变化，及其与癫痫严重程度的相关性。方法：应用散射比浊法检测57例未服药癫痫患者、46例规律服药三个月以上癫痫患者及54例健康对照组外周血免疫球蛋白、补体浓度，，对未服药癫痫患者使用NHS3量表评估癫痫严重程度。结果：症状性癫痫组、非症状性癫痫组未服药前外周血清IgG、IgA浓度均较对照组明显下降（P 0.05），而外周血清IgM、C3、C4浓度与对照组相比差异无统计学意义。多因素Logistic回归分析提示癫痫严重程度NHS3评分与血清IgA浓度呈负相关（β值=-4.948，P=0.004）。未服药癫痫患者血清IgG、IgA浓度较正常对照组下降，差异有统计学意义（P 0.05），有癫痫史且经正规抗癫痫药物治疗三月以上组血清IgG、IgA浓度较未服药癫痫组均升高,血清IgG浓度差异有统计学意义，血清IgA浓度差异无统计学意义。结论：癫痫患者在抗癫痫药物治疗前已存在免疫功能的紊乱，且癫痫严重程度与血清IgA浓度呈负相关。抗癫痫药物治疗对癫痫患者的免疫功能改善可能有帮助。
[Abstract]:Objective: to study the changes of immunoglobulin and complement in peripheral blood of epileptic patients and their correlation with the severity of epilepsy. Methods: the concentrations of immunoglobulin and complement in peripheral blood of 57 patients with epilepsy without taking medicine and 54 healthy controls were detected by scatter turbidimetry. NHS3 scale was used to evaluate the severity of epilepsy. Results: the IgA concentration in peripheral blood of symptomatic epilepsy group and non-symptomatic epilepsy group was significantly lower than that of control group (P 0.05), but there was no significant difference between the control group and the control group. Multivariate Logistic regression analysis showed that the NHS3 score of the severity of epilepsy was negatively correlated with the serum IgA concentration (尾 = -4.948, P = 0.004). The level of serum IgGG _ 3 in patients with epilepsy without medication was lower than that in the control group (P 0.05), and the serum IgA level of patients with epilepsy history and more than three months after regular antiepileptic treatment was higher than that of the control group. There was significant difference in serum IgG concentration, but no significant difference in serum IgA concentration. Conclusion: there is a disorder of immune function in epileptic patients before antiepileptic drug therapy, and the severity of epilepsy is negatively correlated with serum IgA concentration. Antiepileptic drug therapy may be helpful to improve the immune function of epileptic patients.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R742.1

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