皮层下脑梗死致认知情感障碍相关危险因素分析

发布时间：2018-05-05 00:17

本文选题：皮层下脑梗死 + 认知障碍　；参考：《吉林大学》2017年硕士论文

【摘要】：目的:本文旨在探讨皮层下脑梗死致认知情感障碍有影响的危险因素,以探求尿微量白蛋白、脑血管狭窄、脑白质损伤对皮层下脑梗死致认知情感障碍的影响。方法:本研究以2014年12月至2016年12月到吉林大学第一医院神经内科就诊的86例皮层下脑梗死患者作为研究对象,通过汉密尔顿焦虑量表、汉密尔顿抑郁量表及Mo CA量表对研究对象分组,根据Ylikoski量表评分、头MRA、颈部彩超、脑部彩超、尿微量白蛋白结果通过统计学方法分析脑大动脉血管狭窄、尿微量白蛋白及脑白质损伤与皮层下脑梗死致认知情感障碍的相关性。结果:1、皮层下脑梗死致认知障碍组与非认知障碍组对脑血管狭窄程度行卡方检验:(X2=52.865,P=0.000)差异有统计学意义。对尿微量白蛋白行卡方检验:尿微量白蛋白(X2=2.296,P=0.13)、脑白质损伤评分行t检验:(t=1.007,P=0.319)差异无统计学意义。2、皮层下脑梗死致情感障碍组与非情感障碍组对尿微量白蛋白行Fisher确切概率法:尿微量白蛋白(X2=15.452,P=0.000)、脑血管狭窄程度行卡方检验:(X2=14.496,P=0.025)差异有统计学意义。对脑白质损伤评分行t检验:(t=0.657,P=0.420)差异无统计学意义。3、皮层下脑梗死致认知障碍伴有情感障碍组与认知障碍不伴情感障碍组尿微量白蛋白行Fisher确切概率法:尿微量白蛋白(X2=7.878,P=0.005)、脑血管狭窄程度行卡方检验:(X2=13.9,P=0.031)差异有统计学意义。对脑白质损伤评分行t检验:(t=0.451,P=0.505)差异无统计学意义。结论:1、皮层下脑梗死致认知功能障碍与脑血管狭窄有关,皮层下脑梗死致认知功能障碍与尿微量白蛋白、脑白质损伤无关。2、皮层下脑梗死致情感功能障碍与尿微量白蛋白、脑血管狭窄有关,皮层下脑梗死致情感功能障碍与脑白质损伤无关。3、皮层下脑梗死致认知功能障碍合并情感障碍与尿微量白蛋白、脑血管狭窄有关,皮层下脑梗死致认知功能障碍合并情感障碍与脑白质损伤无关。
[Abstract]:Objective: to investigate the risk factors of cognitive and affective disorder caused by subcortical cerebral infarction, and to explore the effects of urinary microalbumin, cerebral vascular stenosis and white matter injury on cognitive affective disorder caused by subcortical cerebral infarction. Methods: 86 patients with subcortical cerebral infarction who were admitted to the Department of Neurology, first Hospital of Jilin University from December 2014 to December 2016 were selected as subjects. The subjects were divided into two groups by Hamilton Depression scale and Mo CA scale. According to the scores of Ylikoski, head MRAs, cervical color ultrasound, brain color ultrasound, urine microalbuminuria, the stenosis of cerebral artery was analyzed by statistical method. The correlation between urinary microalbumin and white matter injury and cognitive affective disorder caused by subcortical cerebral infarction. Results there was a significant difference in the degree of cerebral vascular stenosis between the subcortical infarction group and the non-cognitive disorder group. The chi-square test showed that there was a significant difference in the degree of cerebral vascular stenosis between the subcortical infarction group and the non-cognitive disorder group. Chi-square test for urinary microalbumin: urine microalbumin X _ 2H _ (2) 2.296U ~ (0.13), brain white matter injury score: t ~ (1: 007 / P ~ (0.319) No significant difference was found. 2. There was no significant difference between the subcortical cerebral infarction group and the non-affective disorder group. The Fisher of urinary microalbuminuria was confirmed in the subcortical cerebral infarction group and non-affective disorder group. The cut probability method: urine microalbumin X _ 2X _ 2N _ (15.452) P _ (0.000), the degree of cerebral vascular stenosis was measured by chi-square test (X _ (2) X _ (2)) 14.496 (P < 0.025), the difference was statistically significant (P < 0.05). There was no significant difference in the white matter injury score (t test: 0. 657% P0. 420). There was no significant difference. There was no significant difference between the subcortical cerebral infarction group with affective disorder and the group without cognitive disorder with emotion disorder. The exact probability of urinary microalbumin in patients with subcortical cerebral infarction accompanied with affective disorder was: microalbuminuria: microalbuminuria. There was significant difference in the degree of cerebral vascular stenosis by chi-square test (X _ (2) X _ (2) X ~ (13. 9) P ~ (0.031)). There was no significant difference in white matter injury score by t test (t test 0. 451% P 0. 505). ConclusionThe cognitive dysfunction caused by subcortical cerebral infarction is related to cerebral vascular stenosis, and the cognitive dysfunction caused by subcortical cerebral infarction is not related to urinary microalbumin and white matter injury. The affective dysfunction caused by subcortical cerebral infarction is associated with urinary microalbumin. The affective dysfunction caused by subcortical cerebral infarction was not related to white matter injury. The cognitive dysfunction caused by subcortical cerebral infarction was associated with urinary microalbuminuria and cerebrovascular stenosis. Cognitive dysfunction associated with affective disorder caused by subcortical cerebral infarction was not associated with white matter injury.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R743.33

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