脑性瘫痪婴儿的白质脑网络研究

发布时间：2018-05-05 01:42

  本文选题：脑性瘫痪 + 弥散张量成像　； 参考：《生物医学工程学杂志》2017年05期

【摘要】：本文使用弥散张量成像及白质纤维束追踪技术构建和分析了15名脑性瘫痪患儿和30名正常婴儿大脑的白质脑网络,发现脑性瘫痪患儿和正常婴儿的白质脑网络都具有"小世界"属性,但患儿的最短路径长度明显变长,而标准聚类系数、全局效率和局部效率明显下降。此外,我们还发现左脑楔叶、左右脑楔前叶以及左脑扣带回后部是婴儿白质脑网络的核心节点,患儿白质脑网络的部分节点存在异常,且异常节点多集中于颞叶、枕叶和顶叶。本文结果表明脑性瘫痪婴儿的白质脑网络已经出现紊乱的现象,这为我们进一步研究脑性瘫痪儿童的发病机制提供了帮助。
[Abstract]:The white matter brain network of 15 children with cerebral palsy and 30 normal infants was constructed and analyzed by using diffusion Zhang Liang imaging and white matter fiber tracer technique. It was found that the white matter brain network of both children with cerebral palsy and normal infants had the attribute of "small world", but the shortest path length of children became longer, while the standard clustering coefficient, global efficiency and local efficiency decreased obviously. In addition, we also found that the left cuneate lobe, the left and right precuneal lobe and the posterior cingulate gyrus of the left brain are the core nodes of the white matter brain network in infants. Some of the nodes of the white matter brain network in children are abnormal, and the abnormal nodes are mainly concentrated in the temporal lobe, occipital lobe and parietal lobe. The results show that the white matter network of infants with cerebral palsy has been disordered, which is helpful for us to study the pathogenesis of cerebral palsy in children with cerebral palsy.
【作者单位】： 上海理工大学医疗器械与食品学院;
【基金】：国家自然科学基金(61201067) 微创励志创新基金(YS30809134)
【分类号】：O157.5;R742.3
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本文编号：1845636