听觉诱发电位对早期帕金森患者药物治疗后认知功能受损的评估

发布时间：2018-05-05 19:36

本文选题：帕金森病 + 认知　；参考：《重庆医学》2017年23期

【摘要】：目的探讨早期帕金森(PD)患者接受左旋多巴治疗后认知功能受损的情况。方法选择2014年3月至2015年3月期间该院或门诊初诊为原发性PD患者30例,根据患者意愿,选择同意服用左旋多巴17例为PD-T组,不同意服用左旋多巴13例为PD组,以及同期该院15例门诊健康体检者为健康对照组(C组);分别进行简易智能状态检查(MMSE)、听觉诱发电位(AEP)检查。结果治疗前,PD-T组及PD组与C组在MMSE总评分、注意力、计算力和语言能力及N2PL、P300PL、P300Amp等方面比较,差异有统计学意义(P0.05)。经药物治疗后PD-T组在N2PL、P300PL与C组比较差异无统计学意义(P0.05),但在MMSE方面比较差异仍有统计学意义(P0.05);PD-T组与PD组在MMSE、N2PL、P300PL,P300Amp比较差异无统计学意义(P0.05)。PD组与C组在MMSE、N2PL、P300PL、P300Amp比较差异有统计学意义(P0.05)。结论 MMSE、AEP能较客观反映早期PD患者认知功能受损情况;早期PD患者服用左旋多巴治疗对认知功能有一定改善作用。
[Abstract]:Objective to investigate the cognitive impairment in patients with early Parkinson's disease (PD) after levodopa therapy. Methods from March 2014 to March 2015, 30 patients with primary PD were selected from the hospital or outpatient clinic. According to the wishes of the patients, 17 patients were selected as PD-T group and 13 patients as PD group who did not agree to take levodopa. In the same period, 15 cases of outpatient health check-up in this hospital were taken as healthy control group C, MMSEN and AEPs were examined by simple intelligence state examination and auditory evoked potential (AEPs), respectively. Results before treatment, there were significant differences in total MMSE score, attention, computational ability and language ability between PD group and group C, as well as N2PLP P300 PLP P300Amp. There was significant difference between PD group and C group. After drug treatment, there was no significant difference between PD-T group and C group in N2PLN P300PL and C group, but there was still a significant difference in MMSE between PD-T group and PD group. There was no significant difference between PD-T group and PD group in MMSE N2PLP300 PLPLP P300Amp. There was no significant difference between PD group and C group in MMSEN2PLP300 P300Amp. There was no significant difference between PD group and C group in MMSEN2PLP300 P300Amp. Conclusion MMSE AEP can objectively reflect the cognitive impairment in early PD patients, and the treatment of levodopa in early PD patients can improve cognitive function to some extent.
【作者单位】：湖北省武汉市第五医院神经内科;
【基金】：武汉市卫生和计划生育委员会公共卫生科研项目(WG13C21)
【分类号】：R742.5

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