围手术期卒中患者外周血vWF及ADAMTS13检测及临床意义

发布时间：2018-05-07 23:21

本文选题：围手术期卒中 + 内皮损伤　；参考：《中风与神经疾病杂志》2014年12期

【摘要】：目的探讨v WF(血管性血友病因子)、ADAMTS13(血管性血友病因子裂解酶)在围手术期卒中的发生发展中所起的作用。方法收集围手术期内发生缺血性卒中的患者31例做为实验组,将实验组分为腔隙性梗死组、小面积梗死组以及大面积梗死组3个亚组。同时收集48例健康体检者做为对照组。采用酶联免疫吸附法(ELISA)检测v WF抗原、ADAMTS13抗原含量,应用残余胶原结合试验检测ADAMTS13的活性。结果 (1)实验组患者血浆中v WF抗原水平明显高于对照组(P0.05),ADAMTS13活性水平及ADAMTS13抗原含量均明显低于对照组(P0.05)。(2)实验组3个亚组的v WF抗原水平在大面积梗死组最高,腔隙性梗死组最低,大面积梗死组与腔隙性梗死组间差异有显著性(P0.05)。(3)ADAMTS13抗原含量在大面积梗死组最低,腔隙性梗死组最高,3组间差异均具有显著性(均P0.05),ADAMTS13活性水平在3组间差异无显著性(均P0.05)。结论v WF及ADAMTS13参与了围手术期卒中的发生发展,ADAMTS13水平降低及v WF水平升高可能是围手术期卒中发生的危险因素。
[Abstract]:Objective to investigate the role of v WF (von Willebrand factor ADAMTS13) in the development of perioperative stroke. Methods Thirty-one patients with ischemic stroke during perioperative period were divided into three subgroups: lacunar infarction group, small infarct group and large infarct group. At the same time, 48 healthy persons were collected as control group. Enzyme linked immunosorbent assay (Elisa) was used to detect the antigen content of vWF antigen ADAMTS13 and the activity of ADAMTS13 was detected by residual collagen binding test. Results (1) the level of vWF antigen in plasma of the experimental group was significantly higher than that of the control group (P0.05ADAMTS13 activity level and ADAMTS13 antigen content were significantly lower than that of the control group P0.05ADAMTS13) the level of vWF antigen in the three subgroups of the experimental group was the highest in the large area infarction group. The level of ADAMTS13 antigen in large area infarction group was the lowest in large area infarction group, and there was significant difference between large area infarction group and lacunar infarction group. There were significant differences among the three groups in lacunar infarction group (all P0.05ADAMTS13 activity levels were not significantly different among the three groups (all P0.05). Conclusion vWF and ADAMTS13 are involved in the occurrence and development of perioperative stroke. The decrease of ADAMTS13 level and the increase of vWF level may be the risk factors of perioperative stroke.
【作者单位】：淄博市张店区人民医院;沈阳军区总医院神经内科;
【分类号】：R619

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