高血压病程与脑血流动力学及脑白质疏松的相关性研究

发布时间：2018-05-10 14:06

本文选题：高血压病 + 脑血流动力学　；参考：《青岛大学》2014年硕士论文

【摘要】：目的：研究高血压病程与脑血流动力学及脑白质疏松的关系。方法：按照高血压病程长短将实验收集的73例高血压病病人分为四组：A组高血压病程小于5年,B组高血压病程5至10年,C组高血压病程10至20年,D组高血压病程大于20年。健康对照组74例。所有患者行经颅多普勒超声及颅脑MRI检查,记录MCA平均血流速度(Vm)、收缩期峰值血流速度(Vs)、舒张末血流速度(Vd)、搏动指数(PI)及脑白质疏松(LA)严重程度。根据Fazekas量表对LA的严重程度进行半定量分析,分别对侧脑室旁高信号(PVH)和双侧深部白质高信号(DWMH)进行评分。结果：B组、C组的Vm、Vs较对照组显著增快(p0.05)。D组的Vd较对照组显著减慢(p0.05)、PI较对照组显著增大(p0.05)。B组、C组、D组LA的总评分较对照组显著增加(p0.05)。在高血压患者中,年龄、病程、PI、Vd与LA存在明显相关性。控制年龄、病程、Vd后MCA-PI与LA仍相关。结论：(1)高血压患者脑血流速度先增快,随着高血压病程的增长,脑血流速度有逐渐减慢的趋势。(2)MCA-PI与LA显著相关,并且能够预测高血压患者LA病变的严重程度。
[Abstract]:Objective: to study the relationship between the course of hypertension and cerebral hemodynamics and leukoaraiosis. Methods: according to the duration of hypertension, 73 patients with hypertension were divided into four groups: group A, group A, the course of hypertension was less than 5 years and group B, the course of hypertension in group C was 5 to 10 years, and the course of hypertension in group D was 10 to 20 years, and the course of hypertension in group D was more than 20 years. There were 74 cases in the healthy control group. All patients were examined by transcranial Doppler ultrasound and craniocerebral MRI to record the severity of MCA mean blood flow velocity (VMV), peak systolic velocity (VS), end-diastolic flow velocity (VDV), pulsatility index (Pi) and leukoaraiosis (LAA). According to the Fazekas scale, the severity of LA was semi-quantitatively analyzed, and the scores of hyperintense PVHs and hyperintense white matter in the bilateral deep white matter were scored respectively in the lateral paraventricular hyperintensity (PVHs) and bilateral deep white matter hyperintensity (DWMHs). Results compared with the control group, the VmTVs in the control group were significantly slower than those in the control group (P < 0.05). The total LA score of the C group was significantly higher than that of the control group (P 0.05). The total LA score of the C group was significantly higher than that of the control group (P 0.05), and that of the control group was significantly higher than that of the control group (P < 0.05), while that of the control group was significantly lower than that of the control group (P < 0.05). In patients with hypertension, there was a significant correlation between age, course of disease and LA. Control age, MCA-PI and LA were still correlated with the course of disease after VD. Conclusion (1) the cerebral blood flow velocity in hypertensive patients increased first, and with the increase of the course of hypertension, the cerebral blood flow velocity decreased gradually. MCA-PI was significantly correlated with LA and could predict the severity of LA lesions in hypertensive patients.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R544.1;R743

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