视黄醇结合蛋白4与2型糖尿病合并脑梗死的关系研究

发布时间：2018-05-11 09:47

本文选题：脑梗死 + 2型糖尿病　；参考：《石河子大学》2014年硕士论文

【摘要】：目的探讨2型糖尿病合并脑梗死患者血清视黄醇结合蛋白4（RBP4）水平及其意义。方法选取2012年11月—2013年7月在石河子大学第一附属医院住院的30例2型糖尿病患者（DM组）、30例脑梗死患者（CI组）、30例2型糖尿病合并脑梗死患者（DM+CI组）及30例同期体检健康者（对照组）。记录各组受检者的一般信息及实验室检查结果，比较各组血清RBP4水平；采用Spearman’s相关分析RBP4的相关因素；采用二分类Logistic回归分析2型糖尿病并发脑梗死的影响因素。结果（1）4组受检者三酰甘油（TG）、低密度脂蛋白（LDL）、RBP4、糖化血红蛋白（HbA1c）、胱抑素C、同型半胱氨酸（Hcy）水平间有差异（P＜0.05）；其中DM+CI组患者RBP4水平均高于其他3组（P0.05）。（2）血糖控制未达标组（HbA1c＞6.5%）RBP4水平高于血糖控制达标组〔（106.0±23.1）mg/L与（87.8±32.5）mg/L，，t=-3.539；P=0.001〕。（3）血清TC、TG、LDL水平均与RBP4呈正相关（r值分别为0.430、0.432和0.681；P=0.001）。（4）以DM患者是否合并DI做因变量的二分类Logistic回归分析发现RBP4（OR=1.023P=0.046）和Hcy（OR=1.130P=0.040）均为糖尿病合并脑梗死的危险因素。结论（1）2型糖尿病合并脑梗死患者血清RBP4水平升高，提示RBP4可作为2型糖尿病患者并发脑梗死的临床生物学指标；（2）血清RBP4水平升高与血糖控制不达标有关，提示需更改降糖方案；（3）血清TC、TG、LDL水平与RBP4水平呈正相关，提示兼顾血脂治疗的重要性。
[Abstract]:Objective to investigate the level and significance of retinol binding protein 4 (RBP 4) in patients with type 2 diabetes mellitus complicated with cerebral infarction. Methods from November 2012 to July 2013, 30 patients with type 2 diabetes mellitus and 30 patients with cerebral infarction were enrolled in the first affiliated Hospital of Shihezi University. Healthy persons (control group). The general information and laboratory results of each group were recorded to compare the serum RBP4 levels in each group, Spearman's correlation analysis was used to analyze the related factors of RBP4, and two classification Logistic regression analysis was used to analyze the influencing factors of type 2 diabetes mellitus complicated with cerebral infarction. Results there were significant differences in the levels of triacylglycerol (TGG), low density lipoprotein (LDL-C) (RBP4), glycosylated hemoglobin (HbA1cP), cystatin C (C) and homocysteine (Hcyn) between the four groups (P < 0.05), and the RBP4 levels in the DM CI group were higher than those in the other three groups (P0.05. 0. 5, P < 0. 05, P < 0. 05, P < 0. 05). HbA1c > 6.5%)RBP4 levels were significantly higher than those in blood glucose control group (106.0 卤23.1)mg/L and 87.8 卤32.5 mg / L). The serum levels of TCA-TGG were positively correlated with RBP4, respectively, 0.4300.32 and 0.681P0.001n.4. respectively. The results of two-classification Logistic regression analysis of whether DM patients were complicated with DI were found to be diabetes mellitus (RP4ORP 1.023P0.046) and HcyOR1.130P0.040). Risk factors of cerebral infarction. Conclusion the increase of serum RBP4 level in patients with type 2 diabetes mellitus complicated with cerebral infarction suggests that RBP4 can be used as a clinical biological index of type 2 diabetes mellitus complicated with cerebral infarction.) the increase of serum RBP4 level is related to the substandard of blood glucose control. It was suggested that the level of serum TCU TGG / LDL was positively correlated with the level of RBP4, indicating the importance of taking into account the treatment of blood lipids.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R587.1;R743.3

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