脑海绵状血管瘤的自然病程：一个家族性脑海绵状血管瘤病例汇报及文献回顾

发布时间：2018-05-12 03:03

本文选题：颅内海绵状血管瘤 + 颅内出血　；参考：《浙江大学》2014年硕士论文

【摘要】：脑海绵状血管瘤是一种常见的中枢神经系统血管畸形疾病,发病有两种形式：家族性和散发性,家族性往往表现有多个病灶。目前对脑海绵状血管瘤的自然病程发展有较深入的研究。最常见的临床表现为癫痫,其次为颅内出血、头痛、局灶神经功能障碍等。发病位置多位于幕上,常见于大脑半球及脑干。由于研究者对出血事件的定义标准不同,不同文献年出血率的研究结果差异较大。既往有出血病史和女性是明确增加出血风险的重要因素,病灶位置可能是影响出血风险的一个重要因素,而病灶的大小则不影响脑出血的发生率。家族性患者因病灶数目较多,出血风险较高。在选择治疗方案时,患者的年龄、性别、病灶位置、既往出血病史均是需要考虑的因素。本文对1例家族性脑海绵状血管瘤家系进行临床观察及影像学检查,对先证者的自然病程进行介绍,并文献回顾脑海绵状血管瘤的自然病程发展的研究,探讨脑海绵状血管瘤的流行病学及临床表现、出血事件、长期预后及治疗策略。
[Abstract]:Cerebral cavernous hemangioma is a common vascular malformation of the central nervous system. There are two forms of cerebral cavernous hemangioma: familial and sporadic. At present, the natural course of cerebral cavernous hemangioma has been studied. The most common clinical manifestations were epilepsy, followed by intracranial hemorrhage, headache, focal neurological dysfunction and so on. The location of the disease is often located on the tentorium, often in the cerebral hemisphere and brain stem. Due to the different criteria for defining bleeding events, the annual bleeding rates in different literatures vary greatly. Previous history of hemorrhage and women were important factors to increase the risk of hemorrhage. The location of lesion may be an important factor affecting the risk of hemorrhage, but the size of lesion does not affect the incidence of intracerebral hemorrhage. Familial patients have a higher risk of bleeding due to the large number of lesions. Age, sex, location of lesion and history of bleeding were all factors to be considered. A family of familial cavernous hemangioma was studied by clinical observation and imaging examination. The natural course of the proband was introduced, and the development of the natural course of cerebral cavernous hemangioma was reviewed. To investigate the epidemiology and clinical manifestations, bleeding events, long-term prognosis and treatment of cerebral cavernous hemangioma.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.4

【共引文献】