抗血小板联合治疗对老年进展性脑梗死患者神经功能及日常生活能力的影响

发布时间：2018-05-13 07:36

本文选题：抗血小板联合治疗 + 老年　；参考：《中国地方病防治杂志》2017年02期

【摘要】：目的探讨抗血小板联合治疗对老年进展性脑梗死患者神经功能及日常生活能力的影响。方法纳入北京老年医院2015年9月至2016年2月收治的43例进展性脑梗死患者为研究对象,在纠正原发病、对症治疗的基础上采用抗血小板联合治疗。选取同期收治的40例进展性脑梗死的患者为对照组,采用单药抗血小板治疗。对两组治疗前后的神经功能、生活能力进行评价,并测定凝血功能指标,比较症状进展、复发率以及不良反应的情况。结果观察组治疗后的FIB小于对照组,APTT、PT大于对照组,差异有统计学意义(P0.05)。观察组治疗后与对照组在NIHSS评分、MBI评分方面的差异有统计学意义(P0.05)。观察组与对照组在症状进展、复发率方面的差异有统计学意义(P0.05)。两组治疗过程中均未见严重不良反应,观察组的不良反应与对照组的差异无统计学意义(P0.05)。结论抗血小板联合治疗老年进展性脑梗死能够显著改善患者的神经功能和生活能力,延缓症状的进展,降低复发率,且安全可靠,值得推广。
[Abstract]:Objective to investigate the effects of combined antiplatelet therapy on neurologic function and ADL in elderly patients with progressive cerebral infarction. Methods 43 patients with progressive cerebral infarction admitted to Beijing Geriatric Hospital from September 2015 to February 2016 were included in the study. The patients were treated with antiplatelet combined therapy on the basis of correcting primary disease and symptomatic treatment. 40 patients with progressive cerebral infarction in the same period were selected as control group and treated with single-drug anti-platelet therapy. The neurological function and life ability of the two groups were evaluated before and after treatment, and the coagulation function indexes were measured, and the progress of symptoms, recurrence rate and adverse reactions were compared. Results the FIB after treatment in the observation group was lower than that in the control group, and the difference was statistically significant (P 0.05). There was significant difference in NIHSS score between the observation group and the control group after treatment (P 0.05). There were significant differences in symptom progression and recurrence rate between the observation group and the control group (P 0.05). There were no serious adverse reactions in both groups, and there was no significant difference between the observation group and the control group (P 0.05). Conclusion combined antiplatelet therapy can significantly improve the neurological function and life ability of elderly patients with progressive cerebral infarction, delay the progress of symptoms, reduce the recurrence rate, and be safe and reliable, which is worth popularizing.
【作者单位】：北京老年医院;
【分类号】：R743.33

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