急性脑梗死患者血清IL-35、MMP-9与颈动脉粥样硬化斑块稳定性的关系

发布时间：2018-05-13 14:09

本文选题：脑梗死 + 白细胞介素-　；参考：《中风与神经疾病杂志》2017年07期

【摘要】：目的探讨急性脑梗死患者血清白细胞介素-35(IL-35)、基质金属蛋白酶9(MMP-9)与颈动脉粥样硬化斑块稳定性的关系。方法选择急性脑梗死患者89例,应用彩色多普勒超声检查颈动脉斑块,根据颈动脉粥样硬化斑块稳定性分为易损斑块组和稳定斑块组。采用酶联免疫吸附法检测患者血清IL-35、MMP-9水平,并分析IL-35、MMP-9与斑块稳定性的关系。结果颈动脉粥样硬化易损斑块组的患者41例,稳定斑块组的患者48例。易损斑块组血清IL-35水平(17.89±7.21 ng/ml)明显高于稳定斑块组(9.08±3.45 ng/ml)(P0.05)。MMP-9水平易损斑块组(430.36±72.78 ng/ml)亦显著高于稳定斑块组(305.16±45.63 ng/ml)(P0.01),差异均有统计学意义。结论脑梗死患者血清IL-35、MMP-9水平可能与颈动脉斑块稳定性有关。
[Abstract]:Objective to investigate the relationship between serum interleukin-35 (IL-35), matrix metalloproteinase-9 (MMP-9) and carotid atherosclerotic plaque stability in patients with acute cerebral infarction. Methods Eighty-nine patients with acute cerebral infarction were divided into vulnerable plaque group and stable plaque group according to the stability of carotid atherosclerotic plaque. The serum level of IL-35 MMP-9 was detected by Elisa, and the relationship between IL-35 MMP-9 and plaque stability was analyzed. Results 41 cases of carotid atherosclerosis vulnerable plaque group, 48 cases of stable plaque group. The level of serum IL-35 in vulnerable plaque group (17.89 卤7.21 ng / ml) was significantly higher than that in stable plaque group (9.08 卤3.45 ng/ml)(P0.05).MMP-9), and that in vulnerable plaque group (430.36 卤72.78 ng / ml) was significantly higher than that in stable plaque group (305.16 卤45.63 ng / ml). Conclusion the level of serum IL-35-MMP-9 in patients with cerebral infarction may be related to the stability of carotid plaque.
【作者单位】：广西壮族自治区人民医院神经内科;
【基金】：国家自然科学基金资助项目(No.81560210) 广西卫计委资助项目(No.Z2015304)
【分类号】：R743.3

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