河南省2004～2015年0～14岁儿童吉兰-巴雷综合征流行特征分析

发布时间：2018-05-16 02:40

本文选题：吉兰-巴雷综合征 + 流行特征　；参考：《中国疫苗和免疫》2016年06期

【摘要】：目的分析河南省儿童吉兰-巴雷综合征(Guillain-Barre Syndrome,GBS)流行病学特征,为儿童GBS病例的管理和预防提供科学参考。方法用描述性分析方法对2004~2015年河南省报告0~14岁儿童GBS病例进行分析。结果 2004~2015年河南省共报告0~14岁儿童GBS病例1 593例,平均发病率为0.69/10万,各年发病率在0.48/10万(95例,2014年)~0.83/10万(152例,2006年)之间(趋势检验,x2=41.16,P=0.000)。各地区发病率在0.29/10万(58例,信阳市)~1.03/10万(15例,济源市)之间。年龄别发病率在0.22/10万(35例,14岁)~1.86/10万(313例,1岁)之间。男、女性发病率分别为0.81/10万、0.54/10万。6~8月份报告506例(31.76%)。GBS病例肠道病毒分离率为13.81%(220/1 593)。401例(25.17%)病例60天后随访有残留麻痹。结论河南省0~14岁儿童GBS发病率呈逐年下降趋势,以小年龄、男性儿童多发,呈夏秋季高峰。需进一步加强儿童GBS监测和残留麻痹病例的早期康复治疗。
[Abstract]:Objective to analyze the epidemiological characteristics of Guillain-Barre Syndromefus (GBS) in children with Guillain-Barre syndrome in Henan Province, and to provide a scientific reference for the management and prevention of children with GBS. Methods descriptive analysis was used to analyze the GBS cases reported from 2004 to 2015 in children aged 0 to 14 years in Henan Province. Results from 2004 to 2015, 1 593 cases of GBS were reported in Henan Province. The average incidence rate was 0.69 / 100 000. The annual incidence was 0.48 / 100 000 cases, and in 2014 ~ 0.83% / 100 000 cases, 152 cases were reported in Henan Province (trend test: 41.16%, 0.000%). The incidence rate was 0.29 / 100 000 cases in different regions, 10 3 / 100 000 cases in Xinyang City and 15 cases in Jiyuan City. The age-specific incidence was between 0.22 / 100 000 / 35 / 14 years old / 18.6 / 100 000 / 313 / 1 year old. The incidence of enterovirus in male and female were 0.81 / 100 000 and 0.54 / 100,000 respectively. In August, 506 cases with GBS were reported to have residual paralysis after 60 days follow-up. The rate of enterovirus isolation was 13.81 / 220 / 1593 / 401 (P < 0.05). Conclusion the incidence of GBS in children aged 14 years old in Henan Province is decreasing year by year. The incidence rate of GBS in male children is more than that in young age, and it is the peak in summer and autumn. GBS monitoring and early rehabilitation of children with residual paralysis need to be further strengthened.
【作者单位】：河南省疾病预防控制中心;
【基金】：2015年度河南省医学科技攻关计划项目(201504049) 河南省2016年科技攻关项目(162102310036)
【分类号】：R745.43

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