帕金森病患者血清tau蛋白磷酸化水平与预后转归的关系

发布时间：2018-05-16 21:48

  本文选题：帕金森病 + tau蛋白　； 参考：《中国老年学杂志》2017年15期

【摘要】：目的分析帕金森病(PD)患者血清tau蛋白磷酸化水平与预后转归的关系。方法选取接受治疗的PD患者100例作为观察组,另取同期健康体检者100例为对照组。分别采用双抗体夹心酶联免疫吸附法检测所有研究对象的血清磷酸化tau蛋白水平。同时,根据PD患者认知障碍程度的不同分为轻度认知障碍(MCI组)44例及PD痴呆(PDD组)56例,对比两组血清磷酸化tau蛋白水平,此外,将观察组患者根据治疗后PD统一评分量表(UPDRS)评分的不同分为UPDRS35分组以及UPDRS≥35分组,对比两组血清磷酸化tau蛋白水平,并作Spearman相关性分析。结果观察组患者血清磷酸化tau水平为(115.5±56.2)pg/ml,显著高于对照组[(79.7±40.3)pg/ml,P0.05]。MCI组患者血清磷酸化tau水平显著低于PDD组(P0.05)。UPDRS35分组血清磷酸化tau水平显著低于UPDRS≥35分组(P0.05)。经Spearman相关性分析可得,血清磷酸化tau水平与PD患者UPDRS评分呈显著正相关(r=0.563,P=0.011)。结论 PD患者血清tau蛋白磷酸化水平越高,预后越差。
[Abstract]:Objective to analyze the relationship between serum tau protein phosphorylation and prognosis in patients with Parkinson's disease (PD). Methods 100 PD patients were selected as observation group and 100 healthy persons as control group. The levels of serum phosphorylated tau protein were detected by double antibody sandwich enzyme linked immunosorbent assay (Elisa). At the same time, according to the degree of cognitive impairment in PD patients, they were divided into mild cognitive impairment group (44 cases) and PD dementia group (56 cases). The serum levels of phosphorylated tau were compared between the two groups. The patients in the observation group were divided into UPDRS35 group and UPDRS 鈮，

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