核因子-κB激活调控蛋白PRDX4在脑膜瘤组织中的表达及其临床意义

发布时间：2018-05-19 04:38

本文选题：PRDX + 脑膜瘤　；参考：《中国老年学杂志》2017年21期

【摘要】：目的探讨脑膜瘤组织中PRDX4的表达差异及其与临床病理的相关性。方法采用Western印迹和免疫组化(SP法)分析68例脑膜瘤组织、59例配对的瘤旁脑膜组织及45例正常脑膜组织中PRDX4的表达情况,并分析脑膜瘤组织中PRDX4与核因子(NF)-κB活化产物p65的相关性,进一步应用分层分析、生存分析和Cox多元回归分析脑膜瘤患者PRDX4的表达与临床病理及其预后的关系。结果脑膜瘤组织PRDX4蛋白条带灰度值较瘤旁和正常脑膜组织显著增高(P0.001),且瘤旁脑膜组织PRDX4蛋白表达较正常脑膜组织高(P0.05);脑膜瘤PRDX4与NF-κB p65蛋白表达具有显著正相关性(P0.05);且脑膜瘤患者中PRDX4阳性表达与临床分期有显著相关性(P0.01);进一步生存分析发现PRDX4表达阳性者5年无瘤生存期和生存率显著低于阴性者(P0.05),且Cox分析示PRDX4可能是脑膜瘤患者5年无瘤生存预后的独立影响因素(P0.05;RR=1.484;95%CI:1.077~2.260)。结论 NF-κB激活调控蛋白PRDX4可能为早期诊断脑膜瘤的生物学标志,且与脑肿瘤临床分期密切相关,可能具有独立预测脑膜瘤患者5年无瘤生存预后的重要临床价值。
[Abstract]:Objective to investigate the expression of PRDX4 in meningiomas and its correlation with clinicopathology. Methods Western blot and immunohistochemical staining were used to analyze the expression of PRDX4 in 59 matched meningioma tissues and 45 normal meningeal tissues, and the correlation between PRDX4 and NF- 魏 B activator p65 in meningiomas. Furthermore, stratified analysis, survival analysis and Cox multivariate regression analysis were used to analyze the relationship between the expression of PRDX4 and clinicopathology and prognosis in meningioma patients. Results the gray level of PRDX4 protein bands in meningiomas was significantly higher than that in adjacent and normal meninges, and the expression of PRDX4 protein in meningiomas was significantly higher than that in normal meningeal tissues, and there was a significant positive correlation between PRDX4 and NF- 魏 B p65 protein expression in meningiomas. The positive expression of PRDX4 was significantly correlated with the clinical stage in meningioma patients. Further survival analysis showed that the 5-year tumor-free survival time and survival rate of patients with positive PRDX4 expression were significantly lower than that of patients with negative PRDX4 expression, and Cox analysis showed that PRDX4 might be meningeal. The independent factors influencing the survival and prognosis of tumor-free patients in 5 years were P0.05 RRX 1.48495% CI: 1.07772.260. Conclusion the NF- 魏 B activator protein PRDX4 may be a biological marker for early diagnosis of meningioma and closely related to the clinical stage of meningioma. It may have an important clinical value in predicting the survival and prognosis of meningioma patients in 5 years without tumor.
【作者单位】：海南医学院第一附属医院神经外科;
【基金】：海南省社会发展科技专项基金(SF201407)
【分类号】：R739.45

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