应用弥散张量成像研究脑卒中后皮质脊髓束各向异性分数与运动功能的关系

发布时间：2018-05-23 07:40

本文选题：脑卒中 + 皮质脊髓束　；参考：《中国康复理论与实践》2017年07期

【摘要】：目的应用弥散张量成像(DTI)研究脑卒中后皮质脊髓束(CST)的各向异性与运动功能的关系。方法 2013年1月至2016年10月,36例脑卒中患者分别在康复前及8周后行简式Fugl-Meyer评定(FMA)、金子翼上肢功能评定及DTI检查,从内囊后肢、大脑脚、脑桥三个层面,测量病灶侧CST和健侧相应部位的各向异性分数(FA),并进行相关性分析。结果康复前后,在CST 3个不同的层面上,病灶侧FA均显著低于健侧(t5.330,P0.001)。在内囊后肢层面上,病灶侧FA康复后提高(t=-3.415,P0.05),在大脑脚、脑桥层面无显著性差异(t1.653,P0.05);健侧在三个层面上康复前后FA比较均无显著性差异(t1.021,P0.05)。康复前后,三个层面的FA与FMA评分、金子翼上肢功能评分均呈正相关(r0.43,P0.05),其中内囊后肢FA与金子翼上肢功能评分相关性较强(r=0.67)。结论 DTI可用于评估脑卒中后CST损伤及其与运动功能的关系。
[Abstract]:Objective to study the relationship between the anisotropy and motor function of corticospinal bundles (CSTs) after stroke using diffusion Zhang Liang imaging (DTI). Methods from January 2013 to October 2016, 36 patients with cerebral apoplexy were assessed with Fugl-Meyer before and after 8 weeks of rehabilitation. The function of upper limb of pterygoid and DTI were evaluated. The anisotropic fraction of the lesion side CST and the normal side were measured, and the correlation analysis was carried out. Results before and after rehabilitation, FA in the lesion side was significantly lower than that in the normal side on three different levels of CST. On the posterior limb level of the internal capsule, the FA of the lesion side increased the level of the lesion after FA rehabilitation, but there was no significant difference in the cerebral foot and the pons, and there was no significant difference in the FA between the healthy side and the healthy side on the three levels before and after rehabilitation, and there was no significant difference in the FA between the two sides before and after rehabilitation (P 0.05). Before and after rehabilitation, there was a positive correlation between FA and FMA scores on the three layers and the upper limb function score of gold pterygoid. There was a strong correlation between FA of the internal capsule hind limb and the functional score of the upper limb of the gold pterygoid, and there was a strong correlation between FA and the functional score of the upper limb of the gold pterygoid. Conclusion DTI can be used to evaluate CST injury and its relationship with motor function after stroke.
【作者单位】：首都医科大学附属北京康复医院康复诊疗中心;首都医科大学附属北京康复医院放射科;
【分类号】：R493;R743.3

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