重复经颅磁刺激治疗早期帕金森病患者抑郁及睡眠障碍的临床研究

发布时间：2018-05-24 03:58

  本文选题：重复经颅磁刺激 + 帕金森病　； 参考：《临床神经病学杂志》2017年05期

【摘要】：目的探讨重复经颅磁刺激(r TMS)治疗早期帕金森病(PD)抑郁及睡眠障碍的临床疗效。方法选取Hoehn-Yahr分级1~2级的PD患者64例,按照随机数字表法随机分为治疗组(31例)和假刺激组(33例)。治疗组用r TMS 5 Hz高频刺激患者双侧前额叶背外侧(DLPFC)区共10 d,假刺激组接受假刺激治疗共10 d。观察治疗前后两组患者的汉密尔顿抑郁量表(HAMD)、PD睡眠量表(PDSS)、PD统一评定量表第Ⅲ部分(UPDRSⅢ)、外周血IL-6水平、脑内神经递质5-羟色胺(5-HT)、去甲肾上腺素(NE)、多巴胺(DA)含量的变化。结果与治疗前相比,治疗组患者治疗后及治疗后1个月时HAMD评分、UPDRSⅢ评分均明显降低;PDSS评分均明显升高(均P0.05)。与假刺激组同时间点相比,治疗组患者治疗后及治疗后1个月时HAMD评分、UPDRSⅢ评分均明显降低;PDSS评分均明显升高(均P0.05)。与治疗前相比,治疗组患者治疗后外周血IL-6水平及脑内5-HT、NE、DA水平均显著升高(均P0.05)。与假刺激组同时间点相比,治疗组患者治疗后外周血IL-6水平及脑内5-HT、NE、DA水平均显著升高(均P0.05)。结论高频r TMS刺激DLPFC区可短期改善早期PD患者的抑郁及睡眠障碍。
[Abstract]:Objective to investigate the clinical efficacy of repeated transcranial magnetic stimulation (TMS) in the treatment of early PD depression and sleep disorder. Methods Sixty-four PD patients with Hoehn-Yahr grade 1 or 2 were randomly divided into treatment group (n = 31) and sham stimulation group (n = 33). The patients in the treatment group were treated with r TMS 5 Hz high frequency stimulation for 10 days in the bilateral dorsolateral prefrontal cortex, and in the sham stimulation group for 10 days. Before and after treatment, the changes of Hamilton Depression scale (Hamd) and PD Sleep scale (PDSS / PD) were observed. The levels of IL-6 in peripheral blood and the contents of neurotransmitters 5-HT, 5-HT, NE, DA DAA in the brain were measured. Results after treatment and 1 month after treatment, the HAMD score and the UPDRS 鈪，

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