帕金森病患者静息态脑功能局部一致性研究

发布时间：2018-05-24 12:09

本文选题：帕金森病 + 局部一致性　；参考：《临床神经病学杂志》2017年04期

【摘要】：目的探讨帕金森病(PD)患者静息态脑功能局部一致性(ReHo)的变化。方法采集22例原发性PD患者(PD组)和22名健康对照者(正常对照组)的静息态功能磁共振(fMRI)数据,并进行比较。分析PD患者"开"期和"关"期局部一致性(ReHo)值差异有统计学意义的脑区的Re Ho值与PD患者左手对指改善率的相关性。结果与正常对照组比较,PD组"关"期ReHo值的减少主要集中在左侧壳核、双侧小脑半球,而增加的脑区集中在右侧丘脑、左侧额中回、左侧运动前区、右侧顶下小叶、右侧中央后回、双侧辅助运动区、楔前叶。PD组患者"开"期双侧小脑、颞下回、右侧壳核、右侧楔前叶、右侧丘脑、双侧辅助运动区ReHo值较"关"期显著增加;而右侧小脑后叶、右侧颞中回、右侧颞上回、左侧额中回、左侧额上回、右侧后扣带回较"关"期显著。PD患者左手对指改善率为1.59%~126.67%,平均(54.15±38.02)%。Pearson相关性分析结果显示,PD患者右侧丘脑ReHo值与左手对指改善率呈正相关(r=0.637,P0.01)。结论 PD患者静息态脑功能存在广泛异常,左旋多巴对于PD患者的大脑功能环路具有修饰作用。丘脑作为运动环路的一个重要节点,在PD患者中其神经元代谢、功能等也发生了改变。
[Abstract]:Objective to investigate the changes of resting brain function in patients with Parkinson's disease (PD). Methods the resting functional magnetic resonance imaging (fMRI) data of 22 patients with primary PD and 22 healthy controls (normal control group) were collected and compared. To analyze the correlation between the value of re Ho in the brain region of PD patients and the improvement rate of left hand contralateral finger in PD patients. Results in PD group, the decrease of ReHo was mainly in the left putamen nucleus and bilateral cerebellar hemisphere, while the increased brain area was concentrated in the right thalamus, left middle frontal gyrus, left premotor area and right inferior parietal lobule. The ReHo values of bilateral cerebellum, inferior temporal gyrus, right putamen nucleus, right anterior cuneate lobe, right thalamus and bilateral auxiliary motor area in patients with right posterior central gyrus, bilateral auxiliary motor area and bilateral auxiliary motor area were significantly higher than those in "Guan" phase. The right posterior lobe of the cerebellum, the right middle temporal gyrus, the right superior temporal gyrus, the left middle frontal gyrus, the left superior frontal gyrus, The improvement rate of right posterior cingulate gyrus was significantly higher than that of "Guan" stage. The improvement rate of left hand finger in PD patients was 1.596.67. The results of correlation analysis showed that there was a positive correlation between the ReHo value of right thalamus of PD patients and the improvement rate of left contralateral finger. Conclusion there are extensive abnormalities in resting brain function in PD patients. Levodopa can modify the cerebral functional loop in PD patients. As an important node of motor loop, the thalamus has changed its neuronal metabolism and function in PD patients.
【作者单位】：南京医科大学附属脑科医院神经内科;南京医科大学附属脑科医院医学影像科;
【基金】：国家自然科学基金项目(81571348) 江苏省自然科学基金(SBK2015022028) 南京市卫生局计划项目(201402017)
【分类号】：R742.5

【相似文献】