血清TGF-β1、oxLDL、IGF-1与老年脑梗死病情及颈动脉粥样硬化的关系

发布时间：2018-05-24 19:53

本文选题：转化生长因子-β + 氧化型低密度脂蛋白　；参考：《中国老年学杂志》2017年17期

【摘要】：目的探讨血清转化生长因子(TGF)-β1、氧化型低密度脂蛋白(ox LDL)、胰岛素生长因子(IGF)-1在老年脑梗死患者中的变化及其与颈动脉粥样硬化的关系。方法选择2015年6月至2016年6月应用酶联免疫吸附(ELISA)法测定80例老年脑梗死患者及80例老年健康对照者血清TGF-β1、ox LDL、IGF-1水平,应用多普勒超声仪测定两组颈动脉内膜-中层厚度(IMT),应用螺旋CT观察脑梗死患者梗死面积,应用Pearson单因素分析血清TGF-β1、ox LDL、IGF-1与IMT及脑梗死面积的关系。结果脑梗死组血清ox LDL、IGF-1、IMT水平高于对照组,TGF-β1水平低于对照组(P0.05),重度梗死组血清ox LDL、IGF-1及IMT水平高于轻、中度组,且中度组高于轻度组,而TGF-β1水平低于轻、中度组,中度组低于轻度组(P0.05)。脑梗死组斑块发生率高于对照组,且易损斑块组血清ox LDL、IGF-1水平显著高于稳定斑块组,而TGF-β1水平低于稳定斑块组(P0.05)。经Pearson单因素分析可知,ox LDL、IGF-1与脑梗死面积及IMT均呈正相关,而TGF-β1与脑梗死面积及IMT均呈负相关(P0.05)。结论脑梗死患者血清TGF-β1、ox LDL、IGF-1水平升高与脑梗死面积及斑块稳定性有密切的关系。
[Abstract]:Objective to investigate the changes of serum transforming growth factor TGF- 尾 1, oxidized low density lipoprotein (LDL) ox-LDL1 and insulin growth factor (IGF-1) in elderly patients with cerebral infarction and the relationship between TGF- 尾 1, oxidized low density lipoprotein (LDL) and carotid atherosclerosis. Methods from June 2015 to June 2016, the serum levels of TGF- 尾 1ox LDLIGF-1 were measured by Elisa in 80 elderly patients with cerebral infarction and 80 healthy controls. The carotid intima-media thickness (IMT) was measured by Doppler ultrasound. The infarct area of patients with cerebral infarction was observed by spiral CT, and the relationship between serum TGF- 尾 1X LDLIGF-1, IMT and cerebral infarction area was analyzed by Pearson. Results the level of serum TGF- 尾 1 in cerebral infarction group was higher than that in control group (P 0.05). The serum levels of ox LDLL IGF-1 and IMT in severe infarction group were higher than those in mild group, moderate group and mild group, while TGF- 尾 1 level was lower in mild and moderate group than that in mild and moderate group, and the level of TGF- 尾 1 in severe infarction group was lower than that in mild and moderate group. The moderate group was lower than the mild group (P 0.05). The incidence of plaque in cerebral infarction group was higher than that in control group, and the serum level of ox LDL- IGF-1 in vulnerable plaque group was significantly higher than that in stable plaque group, while the level of TGF- 尾 1 was lower than that in stable plaque group (P 0.05). Pearson univariate analysis showed that IGF-1 was positively correlated with cerebral infarction area and IMT, while TGF- 尾 1 was negatively correlated with cerebral infarction area and IMT (P 0.05). Conclusion the increase of serum TGF- 尾 1oxLDLIGF-1 level in patients with cerebral infarction is closely related to the size of cerebral infarction and plaque stability.
【作者单位】：南宁市第三人民医院内科;
【分类号】：R743.33

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