脑出血后铁调素对患者铁代谢及神经功能的影响观察

发布时间：2018-05-25 04:16

本文选题：脑出血 + 铁调素　；参考：《国际神经病学神经外科学杂志》2017年04期

【摘要】：目的观察脑出血后铁调素对患者铁代谢及神经功能的影响。方法以69例高血压脑出血患者为观察组,以于我院行健康体检的69例健康者为对照组。检测2组对象的血清铁调素水平,检测观察组患者血清铁蛋白水平及神经功能指标[血清100β蛋白和血清神经元特异性烯醇化酶(NSE)],并参照改良Ranks’量表(mRS)评估观察组患者预后。根据检测结果,对比分析2组对象的血清铁调素和血清铁蛋白水平;并将观察组69例患者分为I组(Hep20μg/L),II组(Hep于20~30μg/L),III组(Hep≥30μg/L),对比观察3个亚组患者的神经功能指标水平及预后情况。结果观察组患者的平均血清铁调素、铁蛋白水平均高于对照组(P0.05)。在平均血清S100B蛋白和NSE指标值上,III组II组I组(P0.05)。在预后良好率上,I组II组III组(P0.05)。结论脑出血后患者铁调素水平显著升高,引起铁代谢失衡,且其升高趋势与患者神经功能缺损的严重程度及预后不良程度一致。
[Abstract]:Objective to observe the effect of iron modulin on iron metabolism and nerve function in patients with intracerebral hemorrhage. Methods 69 patients with hypertensive intracerebral hemorrhage were selected as observation group and 69 healthy subjects as control group. The levels of serum ferritin, the levels of serum ferritin and neurological function [serum 100 尾 protein and serum neuron specific enolase (NSEs)] were measured in the two groups, and the prognosis of the observation group was evaluated according to the modified Ranks' scale mRSs. According to the results, the levels of serum iron modulin and serum ferritin in two groups were comparatively analyzed, and 69 patients in the observation group were divided into two groups: group I, Hep20 渭 g 路L ~ (-1) 路L ~ (-1) P ~ (-1), group II: Hep > 30 渭 g / L ~ (-1) Hep > 30 渭 g 路L ~ (-1) L ~ (-1), and the neurological function index level and prognosis of the three subgroups were compared. Results the average serum levels of iron modulin and ferritin in the observation group were higher than those in the control group (P 0.05). On the average serum S100B protein and NSE index value, group II, group I, P 0. 05%. The rate of prognosis was better than that of group I, group II, III group (P 0.05). Conclusion the level of iron modulin in patients with intracerebral hemorrhage is significantly increased, which leads to the imbalance of iron metabolism, and the increasing trend is consistent with the severity of neurological deficit and the degree of poor prognosis.
【作者单位】：贵州省黔南州人民医院神经外科;
【分类号】：R743.34

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