DJ-1基因多态性与帕金森病易感性的Meta分析

发布时间：2018-05-25 05:33

本文选题：DJ-基因 + PARK　；参考：《国际神经病学神经外科学杂志》2017年05期

【摘要】：目的评价DJ-1基因多态性与帕金森病(PD)易感性的关系。方法检索知网、万方、Web of Science、Pub Med、EMBASE和Cochrane数据库,检索时间为2001年01月01日至2017年01月01日。确定文献纳入排除标准,并采用Newcastle-Ottawa Scale(NOS)进行质量评估,提取高质量文献的有用部分,使用stata12.0软件进行统计分析。结果共纳入12篇文献,收集到2895组病例和2817组对照,Meta分析结果显示,在帕金森病患者中,DJ-1基因g.168_185del缺失突变(OR=1.26,95%CI:1.06~1.50,P0.05)和c.G293A点突变(OR=2.74,95%CI:1.22~6.16,P0.05)均为PD的危险因素。在g.168_185del与PD相关性研究的亚组分析中,发现非中国人群g.168_185del多态性也是PD的危险因素(OR=1.41,95%CI:1.14~1.73,P0.05),但在中国人群中未发现其相关性(OR=0.98,95%CI:0.72~1.34,P0.05)。c.G293A与PD相关性病例对照研究中均为非中国人群,故未进行亚组分析。结论DJ-1基因g.168_185 del缺失突变和c.G293A点突变是PD的易感因素,但本Meta分析未发现DJ-1基因g.168_185 del缺失突变和c.G293A点突变与中国人群PD具有相关性。
[Abstract]:Objective to evaluate the relationship between DJ-1 gene polymorphism and susceptibility to Parkinson's disease (PD). Methods the databases of Web of Science Pub MedMBASE and Cochrane were retrieved from January 01, 2001 to January 01, 2017. The standard of inclusion and exclusion of literature is determined, and the quality assessment is carried out by using Newcastle-Ottawa scale (NOSs). The useful parts of high quality documents are extracted, and the statistical analysis is carried out with stata12.0 software. Results A total of 12 literatures were included. The results of meta-analysis of 2895 cases and 2817 groups of controls showed that the g.168_185del deletion mutation of DJ-1 gene OR1.2695 and the c.G293A point mutation OR2.74% 95% P0.05 were the risk factors of PD in patients with Parkinson's disease. In the subgroup analysis of the correlation between g.168_185del and PD, it was found that g.168_185del polymorphism in non-Chinese population was also a risk factor for PD. Therefore, no subgroup analysis was carried out. Conclusion the deletion of G. 168185 del and the point mutation of c.G293A in the DJ-1 gene are the susceptible factors of PD. However, there is no correlation between the deletion mutation of DJ-1 gene g. 168185 del and the point mutation of c.G293A in Chinese population by Meta analysis.
【作者单位】：中南大学湘雅二医院神经内科;中南大学湘雅二医院放射科;
【分类号】：R742.5

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