天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的临床观察

发布时间：2018-05-27 01:31

本文选题：型糖尿病 + 脑微血管病变　；参考：《中国药房》2017年15期

【摘要】：目的:观察天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的疗效和安全性。方法:96例老年2型糖尿病伴脑微血管病变患者随机分为对照组(48例)和观察组(48例)。对照组患者给予盐酸二甲双胍片0.5 g,口服,每日3次;观察组患者在对照组治疗的基础上给予天芪降糖胶囊1.6 g,口服,每日3次。两组均用药4周。观察两组患者的临床疗效,治疗前后中医证候总积分、血糖水平[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)]、血脂水平[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、超敏C反应蛋白(hs-CRP)和内皮素-1(ET-1)水平、血液流变学指标、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]及不良反应发生情况。结果:观察组患者总有效率显著高于对照组(89.58%vs.70.83%),差异有统计学意义(P0.05)。治疗后,两组患者中医证候总积分和血糖、hs-CRP、ET-1、TC、TG、LDL-C、血液流变学指标、MDA水平均显著低于同组治疗前,且观察组中医证候总积分、FPG、2 h PG、hs-CRP、ET-1、TC、TG、LDL-C、血液流变学指标、MDA水平均显著低于对照组;两组患者SOD水平均显著高于同组治疗前,且观察组显著高于对照组,同时观察组HDL-C水平显著高于同组治疗前及对照组,差异均有统计学意义(P0.05)。两组患者治疗期间均未见明显不良反应发生。结论:天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的疗效显著,可降低血糖、血脂水平,改善机体血液流变学状态及氧化应激反应,且安全性较好。
[Abstract]:Objective: To observe the efficacy and safety of Tianqi Jiangtang Capsule Combined with metformin in the treatment of senile type 2 diabetes with cerebral microvascular disease. Methods: 96 elderly patients with type 2 diabetes with cerebral microvascular disease were randomly divided into control group (48 cases) and observation group (48 cases). The control group was given 0.5 g of Metformin Hydrochloride Tablets, orally, 3 times a day; On the basis of the control group, the patients were given Tianqi Jiangtang Capsule 1.6 g, oral, 3 times a day. Two groups were used for 4 weeks. The clinical efficacy of the two groups was observed. The total score of TCM syndrome, blood glucose level [FPG), postprandial 2 h blood glucose (2 h PG), glycated hemoglobin (Hb A1c)], blood lipid level [total cholesterol (TC), and three glycerin (T) (T) were observed. G), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)], hypersensitive C reactive protein (hs-CRP) and endothelin -1 (ET-1) level, blood rheology index, oxidative stress index [malondialdehyde (MDA), superoxide dismutase (SOD)] and ungood reaction. Results: the total effective rate of the patients in the observation group was significantly higher than that of the control group (89.5 8%vs.70.83%), the difference was statistically significant (P0.05). After treatment, the total score of TCM syndromes and blood sugar, hs-CRP, ET-1, TC, TG, LDL-C, the hemorrheology index and the level of MDA were significantly lower than those of the same group, and the total score of TCM syndrome, FPG, and 2 h PG in the observation group were significantly lower than those of the two groups. In the control group, the level of SOD in the two groups was significantly higher than that before the same group, and the observation group was significantly higher than the control group. At the same time, the level of HDL-C in the observation group was significantly higher than the same group before and in the control group. The difference was statistically significant (P0.05). There was no obvious adverse reaction in the two groups during the treatment. Conclusion: Tianqi Jiangtang Capsule Combined with metformin. The treatment of senile type 2 diabetes with cerebral microvascular disease has a significant effect. It can reduce blood sugar, blood lipid level, improve the body's Hemorrheology and oxidative stress, and it has good safety.
【作者单位】：唐山市工人医院内分泌科;唐山市工人医院危重症内科;唐山市工人医院呼吸危重症内科;
【分类号】：R587.2;R743

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