省风导痰汤治疗急性脑梗死的临床研究

发布时间：2018-05-27 11:29

本文选题：脑梗死 + 省风导痰汤　；参考：《广州中医药大学》2016年硕士论文

【摘要】：目的：观察省风导痰汤治疗急性脑梗死的临床疗效；探究患者入院时的内皮祖细胞水平、颈动脉形态特征与疗效的相关性。方法：60例病例来源于江门市新会中医院内二科2015年7月至2016年2月期间收治中风(痰证)的患者。全数病例均与《中国急性缺血性脑卒中诊治指南2010》及《中风病诊断与疗效评定标准试行(1995)》的诊断标准切合。随机分为两组,两组年龄、性别差异无统计学意义(P0.05)。两组均给以西医常规基础治疗,观察组在基础治疗方案之上加用省风导痰汤加减,复煎,一天两次,每次100m1,口服。观察指标：美国国立卫生研究院卒中量表(NIHSS评分),在入院前、治疗后第7天、第14天、第21天及第28天时评估;颈动脉狭窄程度及循环内皮祖细胞水平,在入院前评估。全部资料输入SPSS 18.0软件进行统计分析,P0.05为显著性。结果：共选60例患者,随机分入两组。NIHSS评分：总体而言,观察组及对照组受试者的NIHSS评分在不同的治疗方案、不同治疗时程上变化的趋势呈显著的统计学差异(P0.01),观察组疗效明显优于对照组。分组比较,治疗前两组差异无统计学意义(P0.05)；治疗后第7天、第14天,两组差异无统计学意义；第21天和第28天,两组差异有统计学意义,观察组疗效均优于对照组(P0.05),第28天差异显著(P0.01)。康复程度与颈动脉狭窄程度的相关性分析：观察组的康复程度与治疗前颈动脉狭窄程度具有显著的相关性(P0.05),且呈正相关；对照组的康复程度与治疗前颈动脉硬化程度相关性不明显。康复程度与内皮祖细胞水平的相关性分析：观察组的康复程度与治疗前内皮祖细胞水平相关性不明显；对照组的康复程度与治疗前颈动脉硬化程度具有显著的相关性(P0.05),且呈正相关。结论：临床研究的结果显示,相对于单纯西医治疗痰证中风的患者,联合使用省风导痰汤加减在改善临床症状及预后方面疗效更佳。
[Abstract]:Objective: to observe the clinical effect of provincial wind guide phlegm decoction in treating acute cerebral infarction and to explore the correlation of endothelial progenitor cells (EPCs), carotid artery morphology and curative effect in patients with acute cerebral infarction. Methods 60 cases of stroke (phlegm syndrome) were treated from July 2015 to February 2016 in two departments of Xinhui traditional Chinese Medicine Hospital in Jiangmen City. All the cases were in accordance with the diagnostic criteria of the guidelines for the diagnosis and treatment of Acute Ischemic Stroke in China (2010) and the criteria for the diagnosis and Evaluation of Stroke (1995). They were randomly divided into two groups. There was no significant difference in age and sex between the two groups (P 0.05). Both groups were given routine western medicine basic treatment, observation group on the basis of the basic treatment of the combined use of Fengguo phlegm decoction, twice a day, 100 ml, oral. Outcome measures: NIHSS scores were evaluated before admission, 7 days, 14 days, 21 days and 28 days after treatment, and carotid stenosis and circulating endothelial progenitor cell levels were evaluated before admission. All data were inputted into SPSS 18.0 software for statistical analysis. Results: a total of 60 patients were randomly divided into two groups. NIHSS scores: overall, the NIHSS scores of the observation group and the control group were in different treatment plans. There was significant statistical difference in the trend of changes in different treatment stages (P 0.01), and the curative effect of the observation group was significantly better than that of the control group. There was no significant difference between the two groups before treatment (P 0.05); on day 7 and day 14 after treatment, there was no significant difference between the two groups; on day 21 and day 28, the difference between the two groups was statistically significant. The curative effect of the observation group was better than that of the control group (P 0.05), and the difference on the 28th day was significant (P 0.01). The correlation between the degree of rehabilitation and the degree of carotid artery stenosis: in the observation group, there was a significant correlation between the degree of rehabilitation and the degree of carotid artery stenosis before treatment, and there was a positive correlation between the degree of rehabilitation and the degree of carotid artery stenosis. There was no significant correlation between the degree of rehabilitation and the degree of carotid atherosclerosis before treatment in the control group. Correlation analysis between rehabilitation degree and endothelial progenitor cell level: there was no significant correlation between the rehabilitation degree of observation group and the level of endothelial progenitor cell before treatment. There was a significant correlation between the degree of rehabilitation and the degree of carotid atherosclerosis before treatment in the control group, and there was a positive correlation between the degree of rehabilitation and the degree of carotid arteriosclerosis before treatment. Conclusion: the results of clinical study showed that compared with the treatment of phlegm syndrome apoplexy patients with phlegm syndrome by western medicine alone, combined use of Fengguo phlegm decoction was better in improving clinical symptoms and prognosis.
【学位授予单位】：广州中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R743.3

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