脑血流自动调节范围内维持脑血流恒定的因素

发布时间：2018-05-28 17:33

本文选题：脑血流 + 自动调节　；参考：《中国神经精神疾病杂志》2016年01期

【摘要】：目的探讨脑血流自动调节范围内稳定脑血流速度的血流动力学因素。方法利用经颅多普勒检测SD大鼠大脑中动脉的血流速度(cerebral blood flow velocity,CBFV),并同步记录有创动脉血压,绘制自动调节曲线,判断脑血流自动调节上、下限。计算临界关闭压(critical closing pressure,CCP)和血管面积阻力指数(resistance area product,RAP)。分析CCP、RAP与平均动脉压(mean artery blood pressure,MABP)之间的关系。结果动脉血压升高或降低过程中,正常大鼠脑血流自动调节上、下限分别为148.12±7.49 mm Hg、62.96±3.34 mm Hg。脑血流自动调节范围内,CBFV随动脉血压改变轻微(每10 mm Hg MABP,升压:0.65±0.27 cm/s;降压:0.43±0.23 cm/s),而CCP和RAP则随动脉血压明显改变(每10 mm Hg MABP,升压:4.60±1.06 mm Hg、0.11±0.04mm Hg;降压:6.74±0.59 mm Hg、0.09±0.02 mm Hg)。虽然CBFV、CCP、RAP的变化都与MABP相关,但控制CBFV的变动后,CCP和RAP随MABP改变相关性更加明显,其中CCP的变化幅度以及与MABP的相关性明显大于RAP(升压:Beta=0.561、0.418;降压:Beta=0.694、0.266,P均=0.000)。结论大鼠脑血流自动调节有效范围内,脑血流的稳定主要通过CCP和RAP改变对抗动脉血压的变动而实现,尤其是CCP相应升高或降低。
[Abstract]:Objective To investigate the hemodynamic factors of cerebral blood flow in the range of cerebral blood flow . Methods The blood flow velocity ( CBFV ) of the middle cerebral artery of SD rats was detected by TCD . The blood pressure of the cerebral artery was recorded synchronously , the automatic regulation curve was drawn , and the upper and lower limits of cerebral blood flow were determined automatically . The critical closing pressure ( CCP ) and the vascular area resistance index ( RAP ) were calculated . Results Arterial blood pressure of normal rats was 148.12 卤 7.49 mm Hg , 62.96 卤 3.34 mm Hg . The blood pressure of CBFV changed slightly with arterial blood pressure ( blood pressure : 0.43 卤 0.23 cm / s ) , while CCP and RAP changed slightly with arterial blood pressure ( 10 mm Hg MABP , booster : 4.60 卤 1.06 mm Hg , 0.11 卤 0.04 mm Hg ; blood pressure : 6.74 卤 0.59 mm Hg , 0.09 卤 0.02 mm Hg ) . Although the changes of CBFV , CCP and RAP were correlated with MABP , the correlation of CCP and RAP with MABP was more obvious after the change of CBFV . The correlation between CCP and MABP was significantly greater than RAP ( boost : Beta = 0.561 , 0.418 ; Blood pressure : Beta = 0.694 , 0.266 , P = 0.000 ) . Conclusion In the effective range of cerebral blood flow auto - regulation in rats , the stability of cerebral blood flow is mainly realized by changes of CCP and RAP against arterial blood pressure , especially the corresponding increase or decrease of CCP .
【作者单位】：广州市广州医科大学附属第二医院神经内科;中山大学药理实验室;
【基金】：广东省科学技术厅资助项目(编号:2012B031800435) 国家自然科学基金委员会资助项目(编号:81371573)
【分类号】：R743.3

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