脑卒中高危人群血清尿酸水平与颈动脉狭窄的关系

发布时间：2018-05-28 22:38

本文选题：脑卒中 + 尿酸　；参考：《中国老年学杂志》2017年20期

【摘要】：目的探讨血清尿酸(UA)升高合并肥胖、高血压、空腹血糖(FPG)、血脂异常等危险因素与颈动脉狭窄之间的相关性。方法从杭州市下城区朝晖街道筛查出脑卒中高危人群539例,用彩色多普勒超声诊断仪检查颈动脉狭窄程度,同时采用生化自动分析仪检测血清UA、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、FPG、同型半胱氨酸(HCY)和游离脂肪酸(FFA)水平。结果根据UA水平分为第一分位数组181例,第二分位数组178例,第三分位数组180例,3组年龄、体重指数(BMI)、收缩压(SBP)、HDL-C及HCY差异显著(均P0.05)。与第一分位数组比较,第三分位数组LDL-C、FFA、TG、舒张压(DBP)及动脉狭窄发生率显著升高(均P0.05)。UA是脑卒中患者颈动脉狭窄病变的独立危险因素,颈动脉狭窄程度与UA水平有关(OR=1.011,P0.01)。BMI异常组合中,第二和第三分位数组颈动脉狭窄发生率分别是参照组(项目正常+第一分位数组)的1.565、1.686倍(均P0.05)。血压异常组合的颈动脉狭窄发生率分别是参照组的1.488、1.691、1.774倍(均P0.05)。血糖异常组合中,第二和第三分位数组颈动脉狭窄的发生率分别是参照组的1.493、1.574倍(P0.05)。TG异常组合的颈动脉狭窄发生率分别是参照组的1.456、1.639、1.714倍(均P0.05)。FFA异常组合的颈动脉狭窄发生率分别是参照组的1.365、1.580、1.671倍(均P0.05)。HDL-C异常组合的颈动脉狭窄发生率分别是参照组的1.344、1.593、1.699倍(均P0.05)。结论脑卒中高危人群血清UA水平与颈动脉狭窄密切相关,高UA合并肥胖、高血压、血糖和血脂异常等危险因素对颈动脉狭窄的发生具有促进作用。
[Abstract]:Objective to investigate the correlation between elevated serum uric acid UAA and carotid artery stenosis in patients with obesity, hypertension, fasting blood glucose and FPGG, and dyslipidemia. Methods 539 patients with high risk of cerebral apoplexy were screened from Chaohui Street in Xiancheng District of Hangzhou City. The degree of carotid artery stenosis was examined by color Doppler ultrasound. At the same time, the levels of serum UAU, triglyceride TGG, TCU, LDL-CU, HDL-CfG, HCY and FFAs were measured by biochemical automatic analyzer. The results showed that serum UAA, triglyceride (TGN), total cholesterol (TC), low density lipoprotein cholesterol (LDL-CU), high density lipoprotein cholesterol (HDL-C), homocysteine (HCY) and free fatty acid (FFAs) were measured by biochemical analyzer. Results according to UA level, there were significant differences in age, body mass index (BMI), systolic blood pressure (SBP), HDL-C and HCY in 181 cases of the first bit array, 178 cases of the second quartile array and 180 cases of the third position array (all P 0.05). Compared with the first position array, LDL-CnFFATG, DBP and the incidence of arterial stenosis were significantly increased in the third position array (all P0.05).UA were independent risk factors for carotid artery stenosis in stroke patients. The degree of carotid artery stenosis was related to UA level. The incidence of carotid artery stenosis in the second and third position arrays was 1.565v 1.686 times higher than that in the control group (all P 0.05). The incidence of carotid artery stenosis in the combination of abnormal blood pressure was 1.4881.691or 1.774 times higher than that in the control group (all P 0.05). In a combination of abnormal blood sugar, The incidence of carotid artery stenosis in the second and third position array was 1.493n 1.574 times as high as that in the control group (P 0.05N. TG), respectively. The incidence of carotid artery stenosis in the abnormal combination of TG was 1.456n 1.6391.714 times higher than that in the control group. (the incidence of carotid artery stenosis in the abnormal combination of P0.05).FFA was 1.456n 1.6391.714 times higher than that in the control group, respectively. The incidence of carotid artery stenosis in the radiation group was 1.365 and 1.580 and 1.671 times higher than that in the control group (all P 0.05). The incidence of carotid artery stenosis in the abnormal combination of P0.05).HDL-C was 1.344 卤1.5931.699 times of that in the control group (all P < 0.05). Conclusion Serum UA level is closely related to carotid artery stenosis in high risk population of stroke. High UA complicated with obesity, hypertension, abnormal blood glucose and blood lipids can promote the occurrence of carotid artery stenosis.
【作者单位】：浙江中医药大学医学技术学院;
【基金】：浙江省医药卫生平台重点资助课题(2013ZDA005)
【分类号】：R743.3

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