血栓弹力图对大面积脑梗死不同剂量抗血小板聚集药物疗效的评估价值

发布时间：2018-05-28 23:52

本文选题：血小板抑制率 + 大面积脑梗死　；参考：《中国老年学杂志》2017年19期

【摘要】：目的应用血栓弹力图(TEG)评估大面积脑梗死急性期患者高、低剂量阿司匹林联用氯吡格雷对血小板抑制率的影响。方法回顾性纳入北华大学附属医院接诊的急性大面积脑梗死患者,并按阿司匹林口服剂量的不同分为低剂量组(阿司匹林100 mg+氯吡格雷75 mg)52例和高剂量组(阿司匹林300 mg+氯吡格雷75 mg)62例。两组患者均于入院后开始服用阿司匹林及氯吡格雷,于服药第4天,采用TEG检测患者花生四烯酸(AA)途径血小板抑制率和二磷酸腺苷(ADP)途径血小板抑制率。比较两组患者血小板抑制情况及药物抵抗的发生情况。结果低剂量组AA抑制率及ADP抑制率与高剂量组均无统计学差异(均P0.05)。低剂量组发生阿司匹林抵抗及氯吡格雷抵抗与高剂量组无统计学差异(均P0.05)。低剂量组脑梗死出血转化发生率与高剂量组无统计学差异(P0.05)。结论对大面积脑梗死患者,TEG评价的低剂量与高剂量抗血小板聚集治疗对血小板抑制效果无明显差异。
[Abstract]:Objective to evaluate the effect of high and low dose aspirin combined with clopidogrel on platelet inhibition rate in patients with large area cerebral infarction at acute stage by thromboelastography (TEG). Methods the patients with acute large area cerebral infarction admitted to the affiliated hospital of Beihua University were retrospectively included. According to the different oral doses of aspirin, they were divided into low dose group (aspirin 100mg clopidogrel 75 mg)52) and high dose group (aspirin 300mg clopidogrel 75 mg)62). The patients in both groups began to take aspirin and clopidogrel after admission. On the 4th day, the platelet inhibition rate of arachidonic acid (AA) pathway and the platelet inhibition rate of adenosine diphosphate (ADP) pathway were measured by TEG. Platelet inhibition and drug resistance were compared between the two groups. Results there was no significant difference in AA inhibition rate and ADP inhibition rate between low dose group and high dose group (P 0.05). There was no significant difference in aspirin resistance and clopidogrel resistance between low dose group and high dose group (P 0.05). There was no significant difference in the rate of cerebral infarction transformation between the low dose group and the high dose group (P 0.05). Conclusion there is no significant difference between low dose and high dose antiplatelet aggregation therapy in patients with large area cerebral infarction.
【作者单位】：北华大学附属医院;吉林省职业病医院;
【基金】：吉林市科技局发展计划项目(2015年)
【分类号】：R743.33

【相似文献】