血浆Hcy、CysC与腔隙性脑梗死及认知功能的相关性

发布时间：2018-05-29 06:57

  本文选题：同型半胱氨酸 + 胱抑素C　； 参考：《中国老年学杂志》2017年16期

【摘要】：目的探讨腔隙性脑梗死患者血浆同型半胱氨酸(Hcy)、胱抑素(Cys)C的变化及其与认知功能的相关性。方法腔隙性脑梗死患者32例作为观察组,另选取同期无心脑血管疾病的社区健康体检者32例作为对照组。分别检测两组血浆Hcy、CysC水平,并根据蒙特利尔评估量表(MoCA)评分结果将观察组分为认知功能轻度障碍组(20分≤MoCA评分26分)16例、认知功能中度障碍组(15分≤MoCA评分20分)9例、认知功能重度障碍组(MoCA评分15分)7例。应用Spearman相关性分析患者Hcy、CysC水平与认知功能的相关性。结果观察组血浆Hcy、CysC水平显著高于对照组。MoCA评分显著低于对照组(均P0.05)。随着患者认知功能障碍程度的不断增加,其血浆Hcy、CysC水平也呈逐渐上升趋势(均P0.05)。Spearman相关性分析显示,血浆Hcy、CysC与认知功能均呈显著正相关(r=0.562,0.593,P=0.015,0.022)。结论血浆Hcy、CysC与腔隙性脑梗死的发病密切相关,且与患者认知功能障碍呈显著正相关。
[Abstract]:Objective to investigate the changes of plasma homocysteine, cystatin, cystatin C and their correlation with cognitive function in patients with lacunar cerebral infarction. Methods Thirty-two patients with lacunar cerebral infarction were selected as observation group and 32 healthy persons without cardiovascular and cerebrovascular diseases as control group. The plasma levels of cystatin CysC were measured in two groups. According to the results of the Montreal Assessment scale (MMA), the observation group was divided into two groups: mild cognitive impairment group (20 鈮，

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