急性脑梗死患者血清和肽素、NT-proBNP水平变化及其临床意义

发布时间：2018-05-31 12:57

本文选题：急性脑梗死 + 和肽素　；参考：《中国实验诊断学》2016年03期

【摘要】：目的观察急性脑梗死患者血清和肽素、NT-proBNP水平变化情况,探讨两者与急性脑梗死病情的关系及其临床意义。方法选择我院神经内科92例急性脑梗死患者作为研究对象,同期来医院参加体检的90例健康人作为对照组,分别收集他们的一般资料,测定其血清和肽素、NT-proBNP含量,比较两组研究对象及不同病情急性脑梗死患者血清和肽素、NT-proBNP水平变化的差异。结果急性脑梗死轻症组、重症组患者的血清和肽素和NT-proBNP水平高于对照组,差异有统计学意义(P0.05);急性脑梗死重症组患者入院24小时、7天、14天血清和肽素水平分别显著高于轻症组患者对应时间的血清和肽素水平,差异有统计学意义(P0.05);重症组患者入院24小时、7天的NT-proBNP浓度明显高于轻症组患者,差异有统计学意义(P0.05),两组14天的NT-proBNP差异无统计学意义(P0.05)。结论急性脑梗死患者血清和肽素、NT-proBNP水平升高,与急性脑梗死病情、发病时间有关,观察血清和肽素、NT-proBNP水平变化有助临床急性脑梗死的诊断和治疗。
[Abstract]:Objective to observe the changes of serum and peptide NT-proBNP levels in patients with acute cerebral infarction (ACI) and to explore the relationship between NT-proBNP and acute cerebral infarction (ACI) and its clinical significance. Methods 92 patients with acute cerebral infarction (ACI) in neurology department of our hospital were selected as study objects, and 90 healthy persons who took part in physical examination at the same time were selected as control group. Their general data were collected and the contents of NT-proBNP in serum and peptide were measured. The changes of serum and peptide levels of NT-proBNP in patients with acute cerebral infarction were compared between the two groups. Results the levels of serum peptide and NT-proBNP in patients with mild acute cerebral infarction and severe cerebral infarction were higher than those in control group. The levels of serum and peptide in patients with acute cerebral infarction were significantly higher than those in patients with mild cerebral infarction. The concentration of NT-proBNP in the severe group was significantly higher than that in the mild group at 24 hours and 7 days after admission, the difference was statistically significant (P 0.05). There was no significant difference in NT-proBNP between the two groups on the 14th day (P 0.05). Conclusion the elevated levels of NT-proBNP in serum and peptide in patients with acute cerebral infarction are related to the condition and onset time of acute cerebral infarction. It is helpful for the diagnosis and treatment of acute cerebral infarction to observe the changes of NT-proBNP in serum and peptide in patients with acute cerebral infarction.
【作者单位】：北京市社会福利医院;
【分类号】：R743.33

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