脑炎患者感染EV71病毒的流行特点分析

发布时间：2018-06-01 13:20

  本文选题：脑炎 + EV病毒　； 参考：《中国病原生物学杂志》2017年10期

【摘要】：目的了解脑炎患者中感染人肠道病毒71型病毒(human enterovirus 71,EV71)流行特点,为临床感染防控提供指导。方法收集812例脑炎患者临床资料及脑脊液样本,采用RT-PCR扩增检测EV71病毒,分析EV71病毒流行情况。结果经RT-PCR检测,812例脑炎患者中有224例为EV71病毒感染,检出率27.59%。春、夏、秋、冬四季脑炎患者EV71病毒感染率为33.11%、23.02%、22.22%和26.70%,且春季感染率与其他季节相比,差异有统计学意义(χ2=7.4741,P=0.0063)。男性和女性患者感染率分别为30.80%和23.08%,感染率差异有统计学意义(χ2=5.8938,P=0.0152)。儿童、青少年、中老年患者感染率分别为26.64%、20.92%和34.57%;中老年患者感染率与其他年龄患者相比,差异有统计学意义(χ2=9.8285,P=0.0017)。224例患者主要临床表现为突然发病,发热、呕吐、头痛、腹泻、恶心患者分别有182例(81.25%)、164例(73.21%)、155例(69.20%)、63例(28.13%)和26例(11.61%),其他临床表现不明显。224例患者经治疗后,有144例治愈或好转出院,出院时均未发现阳性症状或体征。结论春季为EV71病毒脑炎高发季节,男性中老年患者居多。患者主要表现为突然发病,发热等症状常见。
[Abstract]:Objective to investigate the epidemic characteristics of human enterovirus 71 (enterovirus 71 EV71) in patients with encephalitis and to provide guidance for clinical infection prevention and control. Methods the clinical data of 812 patients with encephalitis and cerebrospinal fluid samples were collected, EV71 virus was detected by RT-PCR amplification, and the prevalence of EV71 virus was analyzed. Results among 812 encephalitis patients detected by RT-PCR, 224 cases were infected with EV71 virus, the detection rate was 27.59%. The infection rate of EV71 virus in the patients with encephalitis in spring, summer, autumn and winter was 33.112.02% and 26.70%, and the infection rate in spring was significantly higher than that in other seasons (蠂 2 7.4741). The infection rates of male and female patients were 30.80% and 23.08, respectively, and the difference was statistically significant (蠂 ~ 2 = 5.8938). The infection rates of children, adolescents and middle-aged and elderly patients were 26.64% and 34.57%, respectively. There was a significant difference in the infection rate between middle and old age patients (蠂 ~ 2 / 9.8285P ~ (0.001717.224). The main clinical manifestations of these patients were sudden onset, fever, vomiting, headache and diarrhea. There were 182 patients with nausea, 164 with 73.21, 155 with 69.20 and 63 with 28. 13. 13) and 26 with 11. 61. The other 224 patients were cured or improved after treatment. No positive symptoms or signs were found at discharge. Conclusion EV71 encephalitis is a high incidence season in spring, male middle-aged and elderly patients are the majority. The main manifestations of the patients were sudden onset, fever and other common symptoms.
【作者单位】： 河南大学淮河医院神经内科;
【分类号】：R512.3
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本文编号：1964321