进展性脑梗死患者颈动脉斑块与炎性因子的相关性

发布时间：2018-06-01 16:53

本文选题：进展性脑梗死 + 颈动脉斑块　；参考：《广东医学》2017年18期

【摘要】：目的探讨进展性脑梗死患者颈动脉斑块与炎性因子的相关性。方法选取进展性脑梗死患者189例(观察组),包括斑块组109例与无斑块组80例。按照斑块性质分为稳定斑块组57例和不稳定斑块组52例。同时选择健康体检者72例(对照组)。采集血清标本,采用酶联免疫吸附法检测血清超敏C反应蛋白(hsCRP)、白细胞介素(IL)-18、基质金属蛋白酶(MMP)-9、IL-6含量。结果观察组血清hs-CRP、IL-18、MMP-9、IL-6含量高于对照组,差异有统计学意义(P0.05);斑块组血清hs-CRP、IL-18、MMP-9、IL-6含量高于无斑块组,差异有统计学意义(P0.05);不稳定斑块组血清hs-CRP、IL-18、MMP-9、IL-6含量高于稳定斑块组,差异有统计学意义(P0.05);血清hs-CRP、IL-18、MMP-9、IL-6与颈动脉斑块稳定性呈负相关。结论进展性脑梗死患者颈动脉斑块稳定性与炎性因子hs-CRP、IL-18、MMP-9、IL-6相关,且呈负相关。
[Abstract]:Objective to investigate the relationship between carotid plaque and inflammatory factors in patients with progressive cerebral infarction. Methods 189 patients with progressive cerebral infarction (observation group, 109 patients with plaque group and 80 patients without plaque group) were selected. According to the character of plaque, 57 cases of stable plaque group and 52 cases of unstable plaque group were divided into two groups. At the same time, 72 healthy persons (control group) were selected. The serum samples were collected and the serum levels of hsCRPX, IL-18, MMP-9 were determined by enzyme-linked immunosorbent assay (Elisa). Results the serum levels of hs-CRP IL-18, MMP-9, MMP-9 and IL-6 in the observation group were higher than those in the control group (P 0.05), the serum hs-CRP IL-18, MMP-9, and IL-6 in the plaque group were higher than those in the non-plaque group (P 0.05), and the levels of hs-CRP IL-18IL-18IL-6 in the unstable plaque group were higher than those in the stable plaque group. The difference was statistically significant (P 0.05), and the serum hs-CRP IL-18, MMP-9, IL-6 was negatively correlated with carotid plaque stability. Conclusion the carotid plaque stability in patients with progressive cerebral infarction is negatively correlated with the inflammatory factor hs-CRP IL-18, MMP-9 and IL-6.
【作者单位】：海南医学院第二附属医院神经内科;
【基金】：海南省科技重点科研课题(编号:2012-812174)
【分类号】：R743.33

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