基于无髓神经模型传导阻断的仿真实验研究

发布时间：2018-06-02 06:34

本文选题：电刺激 + H-H模型　；参考：《北京交通大学》2014年硕士论文

【摘要】：神经纤维通过电活动调节人体机能,而临床中,神经纤维异常兴奋会造成许多功能障碍疾病,研究神经纤维的兴奋传导规律,阻断不必要的神经兴奋,可以恢复某些受损神经的正常功能。因此,寻找适合的电刺激方法,研究神经纤维传导阻断的作用机制和影响因素具有重要的临床意义,可作为治疗手段治愈某些功能障碍疾病。学者们通过对神经纤维的大量研究,建立了许多数学模型进行电刺激下神经传纤维导阻断的仿真研究,并揭示了神经纤维电活动的某些复杂现象。通过神经模型进行研究已经成为神经纤维电位变化研究的最有效方法。本文以无髓神经纤维为研究对象,基于无髓神经纤维的Hodgkin-Huxley (H-H)模型,研究了在高频双向电刺激下无髓神经纤维的阻断阈、影响因素和阻断机制,并提出电刺激结束后轴突恢复刺激前初始状态的恢复时间测量以及恢复机制。本文的主要工作有： 1)建立了基于H-H模型的无髓神经传导阻断系统,在高频双向电流刺激下得出不同直径神经纤维的阻断阈,并确定最小阻断频率为5kHz； 2)研究了无髓神经模型产生传导阻断的作用机制,即钾离子通道的激活,使其产生传导阻断现象。确定了温度和电极.神经纤维距离对阻断阈的影响； 3)对电刺激的开始和结束后神经纤维的状态进行了全面研究； 4)针对电刺激结束后神经纤维恢复刺激前的初始状态进行了创新的研究。确定不同直径神经纤维的恢复时间,以及离子通道和钠.钾泵的作用机制。
[Abstract]:Nerve fibers regulate the function of human body by electrical activity. In clinic, abnormal stimulation of nerve fibers can cause many diseases of dysfunction, so the regulation of excitatory conduction of nerve fibers is studied, and unnecessary nerve excitations are blocked. It can restore the normal function of some damaged nerves. Therefore, it is of great clinical significance to find suitable electrical stimulation methods and to study the mechanism and influencing factors of nerve fiber conduction blockade, which can be used as a therapeutic method to cure some dysfunctional diseases. Through a large number of researches on nerve fibers, many mathematical models have been established to simulate the blocking of nerve fiber conductance under electrical stimulation, and some complex phenomena of nerve fiber electrical activity have been revealed. The study of neural model has become the most effective method to study the changes of nerve fiber potential. In this paper, the unmyelinated nerve fibers were used as the research object, and based on the Hodgkin-Huxley H-H model of unmyelinated nerve fibers, the blocking threshold, influencing factors and blocking mechanism of unmyelinated nerve fibers under high frequency bidirectional electrical stimulation were studied. The recovery time and mechanism of the initial state before the axon recovery were proposed. The main work of this paper is as follows: 1) an unmyelinated nerve conduction blocking system based on H-H model was established. Under the stimulation of high frequency bidirectional current, the blocking threshold of nerve fibers with different diameters was obtained, and the minimum blocking frequency was determined to be 5 kHz; 2) to study the mechanism of conduction blocking in unmyelinated neural model, that is, the activation of potassium channel. The temperature and electrode are determined. The effect of nerve fiber distance on blocking threshold; 3) the state of nerve fibers at the beginning and the end of electrical stimulation was studied. 4) an innovative study was carried out on the initial state of nerve fibers before stimulation after the end of electrical stimulation. Determine the recovery time of nerve fibers with different diameters, as well as ion channels and sodium. Mechanism of action of potassium pump.
【学位授予单位】：北京交通大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R741

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