经单鼻孔—蝶窦入路垂体腺瘤术后尿崩症的临床分析

发布时间：2018-06-02 15:40

  本文选题：垂体腺瘤 + 经蝶窦入路　； 参考：《福建医科大学》2014年硕士论文

【摘要】：【目的】探讨经单鼻孔-蝶窦入路垂体腺瘤术后尿崩症的影响因素及治疗。 【方法】对2008年12月至2012年12月在我科接受经单鼻孔-蝶窦入路垂体腺瘤切除术病人的临床资料进行回顾性分析。统计其性别、年龄、病程、肿瘤大小、生长方向、肿瘤切除程度、内分泌功能分型等因素，应用t检验、χ2检验等方法进行分析，判定术后尿崩症的影响因素。 【结果】符合本组研究的手术275例，术后24小时内结果不纳入统计，发生尿崩症96例（34.9%），其中暂时型93例，三相型2例，永久型1例。统计显示术后尿崩症的发生与肿瘤大小、生长方向及切除程度相关(P0.05),而与性别、年龄、病程及内分泌功能分型无关(P0.05)。其中微腺瘤和巨大腺瘤术后尿崩症发生率均高于大腺瘤(P0.0167),鞍上生长的垂体腺瘤术后尿崩症发生率显著高于其它生长方向(P=0.000),垂体腺瘤全切除术后尿崩症发生率高于大部分切除(P0.0167)。 【结论】掌握尿崩症发生的相关因素，提高手术技巧，，术中注意保护残余垂体，术后及时诊断和正确治疗是防治垂体腺瘤术后尿崩症的关键。
[Abstract]:Objective: to investigate the influencing factors and treatment of diabetes insipidus after pituitary adenoma operation via single nostril-sphenoid sinus approach. [methods] the clinical data of patients undergoing transsphenoidal pituitary adenoma resection from December 2008 to December 2012 in our department were retrospectively analyzed. Sex, age, course of disease, tumor size, growth direction, tumor excision degree, endocrine function type and other factors were analyzed by means of t test and 蠂 2 test to determine the influencing factors of diabetes insipidus after operation. [results] in 275 cases, the results were not included in the statistics within 24 hours after operation. There were 96 cases of diabetes insipidus, including 93 cases of temporary type, 2 cases of three-phase type and 1 case of permanent type. Statistics showed that the incidence of diabetes insipidus was correlated with tumor size, growth direction and excision degree, but not with sex, age, course of disease and endocrine function classification. The incidence of diabetes insipidus after operation of microadenoma and giant adenoma was higher than that of macroadenoma (P0.0167), the incidence of postoperative diabetes insipidus of pituitary adenoma growing in suprasellar was significantly higher than that of other growth direction (P0. 000), and the incidence of diabetes insipidus after total resection of pituitary adenoma was higher than that after resection of pituitary adenoma (P0. 0167). [conclusion] mastering the related factors of diabetes insipidus, improving operative skills, protecting residual pituitary gland during operation, timely diagnosis and correct treatment after operation are the key to prevent and cure diabetes insipidus after operation.
【学位授予单位】：福建医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R739.41


本文编号：1969305