急性脑梗死及脑出血患者应激状态下肠黏膜屏障功能变化

发布时间：2018-06-03 19:31

本文选题：脑梗死 + 脑出血　；参考：《中国继续医学教育》2016年32期

【摘要】：目的研究急性脑梗死、脑出血患者发病早期肠道屏障功能随病程进展的变化。方法选取2013年9月~2015年12月徐州市中心医院神经内科,并确诊为急性脑梗死、脑出血的患者67例,分别于不同时间点取静脉血(12 h内、24 h、72 h、1周、3个月)。同时选取同期门诊健康体检者54例作为对照组,检测其血浆D-乳酸(D-LAC)、二胺氧化酶(DAO)水平。结果 (1)与正常对照组相比,急性脑梗死、脑出血患者在发病后均出现肠黏膜屏障功能改变,且脑梗死、脑出血组患者在发病24h后较发病初期(12 h内)D-LAC、DAO水平逐渐升高,72 h达到高峰,随后1周血清D-LAC及DAO持续高水平(P0.05);(2)在发病12 h内、24 h、72 h、1周、3个月5个时间段内脑梗死、脑出血患者两组间的D-LAC、DAO水平对比,差异无统计学意义(P0.05)。结论脑梗死及脑出血患者急性期应激状态下均会出现肠黏膜屏障功能的改变,且两者在相同发病时间段内无显著差异。
[Abstract]:Objective to study the changes of intestinal barrier function in patients with acute cerebral infarction and cerebral hemorrhage. Methods 67 patients with acute cerebral infarction and intracerebral hemorrhage were selected from Department of Neurology, Xuzhou Central Hospital from September 2013 to December 2015. Venous blood samples were collected at different time points within 12 h, 24 h, 72 h, 1 week, 3 months. The plasma levels of D-LACU and diamine oxidase (DAO) were measured in 54 healthy persons in the same period as control group. Results 1) compared with the normal control group, the patients with acute cerebral infarction and cerebral hemorrhage all showed changes of intestinal mucosal barrier function and cerebral infarction after the onset of acute cerebral infarction and cerebral hemorrhage. In the ICH group, the level of D-LACN Dao increased gradually within 12 hours after the onset of ICH and reached its peak at 72 hours after the onset. The serum levels of D-LAC and DAO continued to be high at 1 week after the onset of ICH. The serum levels of D-LAC and DAO were maintained at a high level (P0.05) within 12 hours after the onset of ICH, and within 24 hours and 72 hours after the onset of ICH, and within 5 periods of 3 months, the cerebral infarction occurred within 5 periods of 3 months. There was no significant difference in D-LACU Dao level between the two groups (P 0. 05). Conclusion the changes of intestinal mucosal barrier function in patients with cerebral infarction and intracerebral hemorrhage in acute stress state were observed, and there was no significant difference between the two groups in the same period of onset.
【作者单位】：徐州市中心医院神经内科;徐州医学院附属医院神经内科;徐州市中心医院胃肠外科;
【分类号】：R743.3

【相似文献】